A thyroid hormone receptor-dependent glucocorticoid induction.

Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus/metabolism; Chickens/genetics; Chloramphenicol O-Acetyltransferase/biosynthesis/genetics; DNA/genetics/metabolism; Dexamethasone/pharmacology; Drug Synergism; Gene Expression Regulation/drug effects/physiology; Genes, Synthetic; Genetic Vectors; Humans; Molecular Sequence Data; Muramidase/genetics; Promoter Regions, Genetic; Rats; Receptors, Glucocorticoid/drug effects/physiology; Receptors, Progesterone/drug effects/physiology; Receptors, Retinoic Acid/drug effects/physiology; Receptors, Thyroid Hormone/drug effects/physiology; Recombinant Fusion Proteins/biosynthesis/genetics; Regulatory Sequences, Nucleic Acid; Simplexvirus/genetics; Thymidine Kinase/genetics; Triiodothyronine/pharmacology; Tumor Cells, Cultured

Abstract :

[en] Glucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to the discovery of synergism between a thyroid hormone receptor-binding site and a cryptic glucocorticoid-responsive element. Glucocorticoid responsiveness could only be detected in the presence of thyroid hormone and its receptor. This synergism requires the glucocorticoid receptor (GR) DNA-binding domain and is mediated by the transactivation domains. We found that synergism also occurs when the thyroid hormone receptor is replaced by the retinoic acid receptor or the GR is replaced by the progesterone receptor. Synergism is qualitatively independent of the type of thyroid hormone receptor-binding site and promoter. In several combinations of promoter and response elements, including a retinoic acid response element, T3 induction was only seen in the presence of the cryptic glucocorticoid-responsive element, GR, and glucocorticoids.

Disciplines :

Genetics & genetic processes

Author, co-author :

Leers, Joerg

Steiner, Christoff

Renkawitz, Rainer

Muller, Marc ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Language :

English

Title :

A thyroid hormone receptor-dependent glucocorticoid induction.

Publication date :

1994

Journal title :

Molecular Endocrinology

ISSN :

0888-8809

eISSN :

1944-9917

Publisher :

Endocrine Society, Chevy Chase, United States - Maryland

Volume :

Issue :

Pages :

440-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 November 2009

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