Article (Scientific journals)
E3 Ubiquitin ligases and cerebral cortex development in health and disease.
Lambert, Nicolas; MOISE, Martin; Nguyen, Laurent
2022In Developmental Neurobiology
Peer Reviewed verified by ORBi
 

Files


Full Text
Manuscript 1er draft.docx
Author preprint (70.99 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Cerebral cortex development; Malformations of cortical development - E3 Ubiquitin ligase - Ubiquitination - Neurodevelopmental disorders
Abstract :
[en] Cerebral cortex development involves the sequential progression of biological steps driven by molecular pathways whose tight regulation often relies on ubiquitination. Ubiquitination is a post-translational modification involved in all aspects of cellular homeostasis through the attachment of a ubiquitin moiety on proteins. Over the past years, an increasing amount of research has highlighted the crucial role played by ubiquitin ligases in every step of cortical development and whose impairment often leads to various neurodevelopmental disorders. In this review, we focus on the key contributions of E3 ubiquitin ligases for the progression of the different steps of corticogenesis, as well as the pathological consequences of their mutations, often resulting in malformations of cortical development. Finally, we discuss some promising targeted treatment strategies for these diseases based on recent advances in the field.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Neurology
Author, co-author :
Lambert, Nicolas  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
MOISE, Martin  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Nguyen, Laurent  ;  Université de Liège - ULiège > GIGA > GIGA Stem Cells
Language :
English
Title :
E3 Ubiquitin ligases and cerebral cortex development in health and disease.
Publication date :
27 April 2022
Journal title :
Developmental Neurobiology
ISSN :
1932-8451
eISSN :
1932-846X
Publisher :
John Wiley & Sons, Hoboken, Us nj
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 April 2022

Statistics


Number of views
82 (9 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
0
Scopus citations®
without self-citations
0
OpenCitations
 
0
OpenAlex citations
 
0

Bibliography


Similar publications



Contact ORBi