Children; Sunlight Exposure; Supplements; Vitamin D; Endocrinology, Diabetes and Metabolism
Abstract :
[en] BACKGROUND: Vitamin D is a vital lipid-soluble vitamin in the body, helping the growth and development of bones. Vitamin D deficiency in children has several adverse effects. The most important preventative factor is determining the deficiency at an early stage and prescribing vitamin D-containing supplements.
OBJECTIVES: To investigate the vitamin D status of children younger and older than 2 years and determine the utility of prescribing vitamin D supplements.
PATIENTS AND METHODS: Three hundred healthy children who attended the pediatric clinic for routine assessments were enrolled in this study. Their parents were asked to complete a questionnaire, which included questions about demographics, nutrition, and supplements. Blood levels of vitamin D, calcium, and phosphorus were then measured.
RESULTS: The final study consisted of 286 children, 140 males and 146 females, with a mean age of 4.46 ± 2.82 yr. Of these, 218 (76.22%) children, with a mean age of 5.09 ± 2.82 yr, had vitamin D deficiency, and 76 children (23.78%), with a mean age of 2.58 ± 1.88 yr, had normal vitamin D levels (P = 0.001). The mean level of vitamin D was 29.71 ± 14.42 ng/mL in 88 (30.8%) patients up to 2 years and 17.11 ± 14.02 ng/mL in 198 (69.2%) patients older than 2 years (P = 0.0001).
CONCLUSIONS: The vitamin D levels of children aged more than 2 years are lower than those of children aged less than 2 years. Thus, prescribing vitamin D-containing supplements in children older than 2 years may be beneficial.
Disciplines :
Pediatrics
Author, co-author :
Torkaman, Mohammad; Department of Pediatrics, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Abolghasemi, Hassan; Department of Pediatrics, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Amirsalari, Susan; New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Beiraghdar, Fatemeh; Department of Pediatrics, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Afsharpaiman, Shahla; Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Kavehmanesh, Zohreh; Department of Pediatrics, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Khosravi, Mohammad Hossein ; Université de Liège - ULiège ; Students' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Language :
English
Title :
Comparison of the Vitamin D Status of Children Younger and Older Than 2 Years in Tehran: Are Supplements Really Necessary?
Publication date :
April 2016
Journal title :
International Journal of Endocrinology and Metabolism
Moon RJ, Harvey NC, Davies JH, Cooper C. Vitamin D and skeletal health in infancy and childhood. Osteoporos Int. 2014;25(12):2673-84. doi: 10.1007/s00198-014-2783-5. [PubMed: 25138259].
Alonso MA, Pallavicini ZF, Rodriguez J, Avello N, Martinez-Camblor P, Santos F. Can vitamin D status be assessed by serum 25OHD in children?. Pediatr Nephrol. 2015;30(2):327-32. doi: 10.1007/s00467-014-2927-z. [PubMed: 25135619].
Palermo NE, Holick MF. VitaminD, bone health, and other health benefits in pediatric patients. J Pediatr Rehabil Med. 2014;7(2):179-92. doi: 10.3233/PRM-140287. [PubMed: 25096870].
AbdulWahab A, Hammoudeh M, Allangawi M, Al-Khalaf F, Chandra P. Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency. Int J Rheumatol. 2014;2014:465395. doi: 10.1155/2014/465395. [PubMed: 25093022].
Zhang HQ, Teng JH, Li Y, Li XX, He YH, He X, et al. Vitamin D status and its association with adiposity and oxidative stress in schoolchildren. Nutrition. 2014;30(9):1040-4. doi: 10.1016/j.nut.2014.02.024. [PubMed: 25102819].
Stagi S, Bertini F, Cavalli L, Matucci-Cerinic M, Brandi ML, Falcini F. Determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis. J Rheumatol. 2014;41(9):1884-92 doi: 10.3899/jrheum.131421. [PubMed: 25086083].
Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005;135(2):317-22 [PubMed: 15671234].
Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M, et al. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122(2):398-417 doi: 10.1542/peds.2007-1894. [PubMed: 18676559].
Kashi Z, Saeedian F, Akha O, Gorgi M, Emadi S, Zakeri H. Vitamin D deficiency prevalence in summer compared to winter in a city with high humidity and a sultry climate. Endokrynol Pol. 2011;62(3):249-51. [PubMed: 21717408].
Correia A, Azevedo Mdo S, Gondim F, Bandeira F. Ethnic aspects of vitamin D deficiency. Arq Bras Endocrinol Metabol. 2014;58(5):540-4. [PubMed: 25166045].
Neyestani TR, Hajifaraji M, Omidvar N, Eshraghian MR, Shariatzadeh N, Kalayi A, et al. High prevalence of vitamin D deficiency in school-age children in Tehran, 2008: a red alert. Public Health Nutr. 2012;15(2):324-30. doi: 10.1017/S1368980011000188. [PubMed: 21356149].
Ardestani PM, Salek M, Keshteli AH, Nejadnik H, Amini M, Hosseini SM, et al. Vitamin D status of 6-to 7-year-old children living in Isfahan, Iran. Endokrynol Pol. 2010;61(4):377-82. [PubMed: 20806182].
Rabbani A, Alavian SM, Motlagh ME, Ashtiani MT, Ardalan G, Salavati A, et al. Vitamin D insufficiency among children and adolescents living in Tehran, Iran. J Trop Pediatr. 2009;55(3):189-91. doi: 10.1093/tropej/fmn078. [PubMed: 18775944].
Habibesadat S, Ali K, Shabnam JM, Arash A. Prevalence of vitamin D deficiency and its related factors in children and adolescents living in North Khorasan, Iran. J Pediatr Endocrinol Metab. 2014;27(5-6):431-6. doi: 10.1515/jpem-2013-0198. [PubMed: 24519715].
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30. doi: 10.1210/jc.2011-0385. [PubMed: 21646368].
Razzaghy-Azar M, Shakiba M. Assessment of vitamin D status in healthy children and adolescents living in Tehran and its relation to iPTH, gender, weight and height. Ann Hum Biol. 2010;37(5):692-701. doi: 10.3109/03014460903527348. [PubMed: 20166840].
Chlebna-Sokol D, Golec J, Karalus J, Halaba Z, Karczmarewicz E, Konstantynowicz J, et al. The assessement of the vitamin D supply in the population of polish children at the age of 9-12 years: multicentre research: preliminary report. Bon Abstract. 2013;2:192.
Torun E, Kahraman FU, Osmanoglu NK, Kucukkoc M, Donmez T, Orucoglu S, et al. Vitamin D-containing supplements for children between 1-3 years of age: are they essential for bone health?. J Pediatr Endocrinol Metab. 2015;28(1-2):183-8. doi: 10.1515/jpem-2014-0009. [PubMed: 25153579].
Chung IH, Kim HJ, Chung S, Yoo EG. Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels. Ann Pediatr Endocrinol Metab. 2014;19(2):86-90. doi: 10.6065/apem.2014.19.2.86. [PubMed: 25077091].
