Development, Validation and Application of a Targeted LC-MS Method for Quantification of Microcystins and Nodularin: Towards a Better Characterization of Drinking Water
Van Hassel, Wannes; Huybrechts, Bart; Masquelier, Julienet al.
Water Science and Technology; Aquatic Science; Geography, Planning and Development; Biochemistry
Abstract :
[en] Cyanotoxins can be produced in surface waters by cyanobacterial blooms, mostly during summer and early autumn. Intoxications would result from consumption of water contaminated with the potent hepatotoxins, microcystins and nodularin. Therefore, the WHO has set a guideline value for drinking water quality concerning one congener of microcystin. Consequently, the design of a validated, public reference method to detect and quantify the hepatotoxins in drinking water is necessary. During this study, a method was developed to quantify cyanotoxins (eight microcystin congeners and nodularin) in water using liquid chromatography coupled with tandem mass spectrometry. Additionally, bottled and tap water samples were tested for the presence of cyanotoxins. No cyanotoxins were detected in any of the collected water samples. However, quality controls and the results of a proficiency test show the validity of the method.
Research center :
InBios - Integrative Biological Sciences - ULiège Toxins - Service Organic contaminants and additives - Sciensano Risk and -Health Impact Assessment, Sciensano
Development, Validation and Application of a Targeted LC-MS Method for Quantification of Microcystins and Nodularin: Towards a Better Characterization of Drinking Water
AFSCA - Agence Fédérale pour la Sécurité de la Chaîne Alimentaire [BE] F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
In the current version of the text, a mistake was made in the associations of the authors. Our co-author Bart sadly passed away during the writing of the publication. Therefore, a cross has been placed next to his name. During the editing process, a cross was also placed next to the name of the first author. However, the first author is still alive and in good health. We expect this mistake will be fixed in the future.
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