Neuroestrogens in the control of sexual behavior: Past, present, and future

Endocrinology, Diabetes and Metabolism; aromatase; social behavior network; circuit mapping; estrogen synthesis; genomic action; membrane-initiated action

Abstract :

[en] This short review focuses on the mechanisms of action of brain derived estrogens, also called neuroestrogens, on male sexual behavior, one of the best characterized examples of estrogen synthesis/action on behavior. After summarizing the modes of regulation of estrogen synthesis and action in the context of this behavior, we identify questions remaining in our under- standing of how neuroestrogens influence complex behaviors and describe the most recent findings providing a beginning of answers to these questions. These questions relate mostly to the characterization of the circuits formed by aromatase neu- rons, the timing of their regulation and the link between behavior-induced fluctuations in neuronal activity and estrogen synthesis/action. Addressing these questions are key steps to understand how neuroestrogens influence complex behaviors.

Research Center/Unit :

GIGA Neurosciences-Neuroendocrinology - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Cornil, Charlotte ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Neuroendocrinology

Court, Lucas ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Neuroendocrinology

Language :

English

Title :

Neuroestrogens in the control of sexual behavior: Past, present, and future

Publication date :

June 2022

Journal title :

Current Opinion in Endocrine and Metabolic Research

eISSN :

2451-9650

Publisher :

Elsevier BV

Volume :

Pages :

100334

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S2451965022000199?httpAccept=text/xml

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 30 March 2022

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