Article (Scientific journals)
Changes of Spasticity across Time in Prolonged Disorders of Consciousness: A Retrospective Study.
Winters, Benjamin; Kuluris, Bruce; Pathmanaban, Rita et al.
2022In Brain Sciences, 12 (2), p. 295
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Keywords :
disorders of consciousness; minimally conscious state; severe brain injury; spasticity; unresponsive wakefulness syndrome; vegetative state; Neuroscience (all); General Neuroscience
Abstract :
[en] OBJECTIVES: In this retrospective study, we investigated how spasticity developed in patients diagnosed with a prolonged DOC over an almost two-year observation period (21 months), and how it related to the patients' age, gender, time since injury, etiology, level of consciousness, and anti-spastic medications. METHODS: In total, 19 patients with a severe brain injury and prolonged DOC admitted to a long-term care facility were included in this study (14 male, age: 45.8 ± 15.3 years, 10 traumatic brain injury, 1.01 ± 0.99 years after brain injury, 11 minimally conscious state vs. 8 vegetative state). Each patient was assessed at admission and then quarterly, totaling eight assessments over 21 months. Spasticity was measured with the Modified Ashworth Scale (MAS) for both upper and lower limbs. The Western Neuro Sensory Stimulation Profile (WNSSP) was administered to assess the level of consciousness. Any other medical and demographic information of interest was obtained through medical records. Linear mixed models were used to assess each variable's impact on the change of spasticity over time. RESULTS: Significant differences were observed in the evolution of spasticity in patients based on their etiology for the upper limbs [F (7, 107.29) = 2.226; p = 0.038], and on their level of consciousness for the lower limbs [F (7, 107.07) = 3.196; p = 0.004]. CONCLUSION: Our preliminary results suggest that spasticity evolves differently according to the type of brain lesion and the level of consciousness. Spasticity in DOCs might therefore be mediated by different mechanisms and might have to be treated differently among patients. Future longitudinal studies should be performed prospectively in a bigger cohort and with data collection beginning earlier after brain injury to confirm our results and better understand the evolution of spasticity in this population.
Disciplines :
Neurology
Author, co-author :
Winters, Benjamin;  Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA
Kuluris, Bruce;  Neurorestorative, CA, USA
Pathmanaban, Rita;  Neurorestorative, CA, USA
Vanderwalt, Hannelise;  Neurorestorative, CA, USA
Thibaut, Aurore  ;  Université de Liège - ULiège > Département des sciences cliniques
Schnakers, Caroline ;  Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA 90095, USA ; Research Institute, Casa Colina Hospital and Centers for Healthcare, Pomona, CA 91767, USA
Language :
English
Title :
Changes of Spasticity across Time in Prolonged Disorders of Consciousness: A Retrospective Study.
Publication date :
21 February 2022
Journal title :
Brain Sciences
eISSN :
2076-3425
Publisher :
MDPI, Switzerland
Volume :
12
Issue :
2
Pages :
295
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 March 2022

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