[en] The sensitivity of a bacterium to beta-lactam antibiotics depends upon the interplay between 3 independent factors: the sensitivity of the essential penicillin-binding enzyme(s), the quantity and properties of the beta-lactamase(s) and the diffusion barrier that the outer-membrane of Gram-negative bacteria can represent. Those three factors can be modified by mutations or by the horizontal transfer of genes or portions of genes.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Frère, Jean-Marie ; Université de Liège - ULiège > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines
Joris, Bernard ; Université de Liège - ULiège > Centre d'ingénierie des protéines
Granier, B.; Université de Liège - ULiège > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines
Matagne, André ; Université de Liège - ULiège > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines
Ackerman, Francine ; Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
Bourguignon-Bellefroid, C.; Université de Liège - ULiège > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines
Language :
English
Title :
Diversity of the Mechanisms of Resistance to Beta-Lactam Antibiotics
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