Platelet transfusion; Red blood cell transfusion; Retinopathy of prematurity; Pediatrics, Perinatology and Child Health; Developmental Biology
Abstract :
[en] AIM: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants.
METHODS: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group).
RESULTS: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020-1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566-3.998) numbers were associated with ROP development.
CONCLUSIONS: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.
Disciplines :
Pediatrics
Author, co-author :
Hengartner, Tobias; Newborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland, tobias.hengartner@uzh.ch
Adams, Mark; Newborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland
Pfister, Riccardo E ; Department of Child and Adolescent, University Hospital Geneva, Geneva, Switzerland
Snyers, Diane ; Centre Hospitalier Universitaire de Liège - CHU > > Service néonatologie (CHR) ; Department of Neonatology, University Hospital Lausanne, Lausanne, Switzerland
McDougall, Jane; Department of Neonatology, University Hospital Berne, Berne, Switzerland
Waldvogel, Salome; Department of Neonatology, University of Basel Children's Hospital, Basel, Switzerland
Held-Egli, Katrin; Department of Neonatology, Children's Clinic, Cantonal Hospital Aarau, Aarau, Switzerland
Spring, Lea; Department of Neonatology, Children's Hospital of Lucerne, Lucerne, Switzerland
Rogdo, Bjarte; Neonatal and Paediatric Intensive Care Unit, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland
Riedel, Thomas ; Paediatric and Neonatal Intensive Care Unit, Department of Paediatrics, Cantonal Hospital Graubuenden, Chur, Switzerland
Arlettaz Mieth, Romaine ; Newborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland
Swiss Neonatal Network
Language :
English
Title :
Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity.
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