Reproducibility of CT-Based Hepatocellular Carcinoma Radiomic Features across Different Contrast Imaging Phases: A Proof of Concept on SORAMIC Trial Data.
CT radiomics; domain translation; hepatocellular carcinoma; reproducibility; Oncology; Cancer Research
Abstract :
[en] Handcrafted radiomic features (HRFs) are quantitative imaging features extracted from regions of interest on medical images which can be correlated with clinical outcomes and biologic characteristics. While HRFs have been used to train predictive and prognostic models, their reproducibility has been reported to be affected by variations in scan acquisition and reconstruction parameters, even within the same imaging vendor. In this work, we evaluated the reproducibility of HRFs across the arterial and portal venous phases of contrast-enhanced computed tomography images depicting hepatocellular carcinomas, as well as the potential of ComBat harmonization to correct for this difference. ComBat harmonization is a method based on Bayesian estimates that was developed for gene expression arrays, and has been investigated as a potential method for harmonizing HRFs. Our results show that the majority of HRFs are not reproducible between the arterial and portal venous imaging phases, yet a number of HRFs could be used interchangeably between those phases. Furthermore, ComBat harmonization increased the number of reproducible HRFs across both phases by 1%. Our results guide the pooling of arterial and venous phases from different patients in an effort to increase cohort size, as well as joint analysis of the phases.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Ibrahim, Abdalla ; The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands ; Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands ; Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege and GIGA CRC-In Vivo Imaging, University of Liege, 4000 Liege, Belgium ; Department of Nuclear Medicine and Comprehensive Diagnostic Center Aachen (CDCA), University Hospital RWTH Aachen University, 52074 Aachen, Germany
Widaatalla, Yousif; The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands
Refaee, Turkey ; The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands ; Department of Diagnostic Radiology, Faculty of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia
Primakov, Sergey; The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands ; Department of Nuclear Medicine and Comprehensive Diagnostic Center Aachen (CDCA), University Hospital RWTH Aachen University, 52074 Aachen, Germany
Miclea, Razvan L; Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
Öcal, Osman ; Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
Fabritius, Matthias P ; Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
Ingrisch, Michael; Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
Ricke, Jens; Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
HUSTINX, Roland ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Mottaghy, Felix M; Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands ; Department of Nuclear Medicine and Comprehensive Diagnostic Center Aachen (CDCA), University Hospital RWTH Aachen University, 52074 Aachen, Germany
Woodruff, Henry C ; The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands ; Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
Seidensticker, Max; Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany
Lambin, Philippe ; Université de Liège - ULiège > Département des sciences cliniques ; The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands ; Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands
Reproducibility of CT-Based Hepatocellular Carcinoma Radiomic Features across Different Contrast Imaging Phases: A Proof of Concept on SORAMIC Trial Data.
H2020 - 733008 - IMMUNOSABR - Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer
Funders :
ERC - European Research Council EU - European Union KWF - Kankerbestrijding
Funding text :
Funding: The authors acknowledge financial support from the ERC advanced grant (ERC-ADG-2015 n◦ 694812-Hypoximmuno). The authors also acknowledge financial support from the European Union’s Horizon 2020 research and innovation programme under grant agreement: ImmunoSABR n◦ 733008, MSCA-ITN-PREDICT n◦ 766276, CHAIMELEON n◦ 952172, EuCanImage n◦ 952103, TRANSCAN Joint Transnational Call 2016 (JTC2016 CLEARLY n◦ UM 2017-8295). The authors further acknowledge financial support by the Dutch Cancer Society (KWF Kankerbestrijding), project number 12085/2018-2, and Maastricht-Liege Imaging Valley grant, project no. “DEEP-NUCLE”.The authors acknowledge financial support from the ERC advanced grant (ERC-ADG-2015 n? 694812-Hypoximmuno). The authors also acknowledge financial support from the European Union?s Horizon 2020 research and innovation programme under grant agreement: ImmunoSABR n? 733008, MSCA-ITN-PREDICT n? 766276, CHAIMELEON n? 952172, EuCanImage n? 952103, TRANSCAN Joint Transnational Call 2016 (JTC2016 CLEARLY n? UM 2017-8295). The authors further acknowledge financial support by the Dutch Cancer Society (KWF Kankerbestrijding), project number 12085/2018-2, and Maastricht-Liege Imaging Valley grant, project no. ?DEEP-NUCLE?.
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