[en] Laminitis is a pathology of the equine digit leading to a failure of the dermo-epidermal
interface. Neutrophil activation is recognized as a major factor in SIRS-associated
laminitis. Less is known about the role of neutrophil activation in laminitis associated
with metabolic disorders. The aim of this descriptive study was to observe
whether myeloperoxidase is increased in the laminae during early stage laminitis in
three horses subjected to a prolonged euglycemic hyperinsulinemic clamp (pEHC).
After 48 h of pEHC-treatment, horses were subjected to euthanasia. Two healthy
horses are used as control. Histological sections of lamellar tissue from all horses
were immunohistochemically stained for myeloperoxidase and counterstained with
hematoxylin-eosin. Histopathological changes that characterize insulin-induced laminitis
and increased presence of myeloperoxidase, especially in the dermal lamellae, were
increased in histologic sections of pEHC-treated horses. Neutrophil myeloperoxidase
release may contribute to the pathophysiology of endocrinopathic laminitis.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Storms, Nazaré ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH)
Medina Torres, Carlos
Franck, Thierry ; Université de Liège - ULiège > Centres généraux > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Guitart, Albert
de la Rebière de Pouyade, Geoffroy ; Université de Liège - ULiège > Département d'Enseignement et de Clinique des Equidés (DCE) > Chirurgie des équidés
Serteyn, Didier ; Université de Liège - ULiège > Département d'Enseignement et de Clinique des Equidés (DCE) > Chirurgie des équidés
Language :
English
Title :
Presence of Myeloperoxidase in Lamellar Tissue of Horses Induced by an Euglycemic Hyperinsulinemic Clamp
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