COVID-19; child health; health systems; prevention strategies; screening
Abstract :
[en] INTRODUCTION: The global COVID-19 pandemic has presented extraordinary disruption to healthcare services and exposed them to numerous challenges. Newborn screening (NBS) programmes were also affected; however, scarce data exist on the impact of COVID-19 on NBS. METHODS: We conducted an international survey to assess the global impact of COVID-19 on NBS, with the main aim of gathering the experiences of the COVID-19 pandemic from a large and representative number of NBS centres worldwide. RESULTS: The results of our study showed that COVID-19 impacted the NBS programmes, at least partially, in 29 out of 38 responding countries. Majority of the screening centres experienced a broad spectrum of difficulties and most were affected more in the second wave of the pandemic. Delays and unreliability with the postal service as well as flight cancellations caused delays in samples arriving to screening centres and with the provision of laboratory equipment and reagents. The availability of laboratory staff was sometimes reduced due to infection, quarantine or reassignment within the healthcare facility. Sample collection at home, second-tier tests and follow-up were also affected. Social restrictions and interruptions in public transport added to these difficulties. Only a limited number of centres managed to retain a fully functioning NBS programme. CONCLUSION: As the pandemic might continue or could recur in future years, it would be useful to develop guidelines to protect these valuable services.
Disciplines :
Pediatrics
Author, co-author :
Koracin, Vanesa; Department of Endocrinology, Diabetes and Metabolism, UMC - University Children's
Loeber, J Gerard; International Society for Neonatal Screening (ISNS) Office, Bilthoven, The
Mlinaric, Matej; Department of Endocrinology, Diabetes and Metabolism, UMC - University Children's
Battelino, Tadej; Department of Endocrinology, Diabetes and Metabolism, UMC - University Children's
Bonham, James R; Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK.
Groselj, Urh ; Department of Endocrinology, Diabetes and Metabolism, UMC - University Children's
COVID-NBS ISNS global, network
Other collaborator :
Greaves, Ronda
Junek, Rosie
Zeyda, Maximilian
BOEMER, François ; Centre Hospitalier Universitaire de Liège - CHU > > Service de génétique
WHO coronavirus (COVID-19) Dashboard. Available: https://covid19.who.int/ [Accessed 20 Apr 2021].
Iftimie S, López-Azcona AF, Vallverdú I, et al. First and second waves of coronavirus disease-19: a comparative study in hospitalized patients in Reus, Spain. PLoS One 2021;16:e0248029.
Du R-H, Liang L-R, Yang C-Q, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study. Eur Respir J 2020;55:2000524.
Lanpher B, Brunetti-Pierri N, Lee B. Inborn errors of metabolism: the flux from Mendelian to complex diseases. Nat Rev Genet 2006;7:449-59.
Tam SS, Picoraro JA, Gupta SK, et al. Changes to pediatric gastroenterology practice during the COVID-19 pandemic and lessons learned: an international survey of division and group heads. Gastroenterology 2021;161:1052-5.
Wilcken B, Wiley V, Hammond J, et al. Screening newborns for inborn errors of metabolism by tandem mass spectrometry. N Engl J Med 2003;348:2304-12.
Centers for Disease Control and Prevention (CDC). CDC grand rounds: newborn screening and improved outcomes. MMWR Morb Mortal Wkly Rep 2012;61:390-3.
Harms E, Olgemöller B. Neonatal screening for metabolic and endocrine disorders. Dtsch Arztebl Int 2011;108:11-21.
Loeber JG, Platis D, Zetterström RH, et al. Neonatal screening in Europe revisited: an ISNS perspective on the current state and developments since 2010. Int J Neonatal Screen 2021;7:15.
Therrell BL, Padilla CD, Loeber JG, et al. Current status of newborn screening worldwide: 2015. Semin Perinatol 2015;39:171-87.
Elmonem MA, Belanger-Quintana A, Bordugo A, et al. The impact of COVID-19 pandemic on the diagnosis and management of inborn errors of metabolism: a global perspective. Mol Genet Metab 2020;131:285-8.
Association of Public Health Laboratories. Impacts to state newborn screening programs form SARS-CoV-2 pandemic.
Greaves RF, Pitt J, McGregor C. Newborn bloodspot screening in the time of COVID-19. Genet Med 2021:1-8.
Kotlyar AM, Grechukhina O, Chen A, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol 2021;224:35-53.
Ozalp M, Demir O, Akbas H, et al. Effect of COVID-19 pandemic process on prenatal diagnostic procedures. J Matern Fetal Neonatal Med 2021;34:1-6.
Adams JG, Walls RM. Supporting the health care workforce during the COVID-19 global epidemic. JAMA 2020;323:1439-40.
Kayikcioglu M, Tokgozoglu L, Tuncel OK, et al. Negative impact of COVID-19 pandemic on the lifestyle and management of patients with homozygous familial hypercholesterolemia. J Clin Lipidol 2020;14:751-5.
Gold JI, Campbell IM, Ficicioglu C. Provider perspectives on the impact of the COVID-19 pandemic on newborn screening. Int J Neonatal Screen 2021;7:38.
Ge H, Wang X, Yuan X, et al. The epidemiology and clinical information about COVID-19. Eur J Clin Microbiol Infect Dis 2020;39:1011-9.
Clayton PT. Is susceptibility to severe COVID-19 disease an inborn error of metabolism? J Inherit Metab Dis 2020;43:906-7.
Sechi A, Macor D, Valent S, et al. Impact of COVID-19 related healthcare crisis on treatments for patients with lysosomal storage disorders, the first Italian experience. Mol Genet Metab 2020;130:170-1.
Osterrieder A, Cuman G, Pan-Ngum W, et al. Economic and social impacts of COVID-19 and public health measures: results from an anonymous online survey in Thailand, Malaysia, the UK, Italy and Slovenia. BMJ Open 2021;11:e046863.
