Article (Scientific journals)
GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.
Pellegrino, Giuliana; Martin, Marion; Allet, Cécile et al.
2021In Nature Neuroscience, 24 (12), p. 1660-1672
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Abstract :
[en] Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during postnatal development. Here, we show that rodent GnRH neurons use a prostaglandin D(2) receptor DP1 signaling mechanism during infancy to recruit newborn astrocytes that 'escort' them into adulthood, and that the impairment of postnatal hypothalamic gliogenesis markedly alters sexual maturation by preventing this recruitment, a process mimicked by the endocrine disruptor bisphenol A. Inhibition of DP1 signaling in the infantile preoptic region, where GnRH cell bodies reside, disrupts the correct wiring and firing of GnRH neurons, alters minipuberty or the first activation of the hypothalamic-pituitary-gonadal axis during infancy, and delays the timely acquisition of reproductive capacity. These findings uncover a previously unknown neuron-to-neural-progenitor communication pathway and demonstrate that postnatal astrogenesis is a basic component of a complex set of mechanisms used by the neuroendocrine brain to control sexual maturation.
Disciplines :
Pediatrics
Endocrinology, metabolism & nutrition
Author, co-author :
Pellegrino, Giuliana;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Martin, Marion;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Allet, Cécile ;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Lhomme, Tori;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Geller, Sarah;  Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Franssen, Delphine ;  Neuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, Belgium.
Mansuy, Virginie;  Service of Endocrinology, Diabetology and Metabolism, University Hospital and
Manfredi-Lozano, Maria;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Coutteau-Robles, Adrian;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Delli, Virginia;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Rasika, S ;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Mazur, Danièle;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Loyens, Anne;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Tena-Sempere, Manuel ;  Department of Cell Biology, Physiology and Immunology, University of Cordoba,  ; Instituto Maimonides de Investigación Biomédica de Cordoba (IMIBIC/HURS), Cordoba,  ; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III
Siepmann, Juergen;  Univ. Lille, Inserm, CHU Lille, U1008, Lille, France.
Pralong, François P;  Service of Endocrinology, Diabetology and Metabolism, University Hospital and
Ciofi, Philippe;  Inserm U1215, Neurocentre Magendie, Bordeaux, France. ; University of Bordeaux, Bordeaux, France.
Corfas, Gabriel ;  Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck
PARENT, Anne-Simone ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Ojeda, Sergio R;  Division of Neuroscience, Oregon National Primate Research Center-Oregon Health &
Sharif, Ariane ;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
Prevot, Vincent ;  Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the
More authors (12 more) Less
Language :
English
Title :
GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.
Publication date :
December 2021
Journal title :
Nature Neuroscience
ISSN :
1097-6256
eISSN :
1546-1726
Publisher :
Nature Publishing Group, Gb
Volume :
24
Issue :
12
Pages :
1660-1672
Peer reviewed :
Peer Reviewed verified by ORBi
Funding number :
R01 HD084542/HD/NICHD NIH HHS/United States; P51 OD011092/OD/NIH HHS/United States
Commentary :
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
Available on ORBi :
since 22 February 2022

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