[en] Personality changes are frequently described by caregivers of patients with Alzheimer's disease, while they are less often reported by the patients. This relative anosognosia of Alzheimer disease (AD) patients for personality changes might be related to impaired self-judgment and to decreased ability to understand their caregiver's perspective. To investigate this issue, we explored the cerebral correlates of self-assessment and perspective taking in patients with mild AD, elderly and young volunteers. All subjects assessed relevance of personality traits adjectives for self and a relative, taking either their own or their relative's perspective, during a functional imaging experiment. The comparison of subject's and relative's answers provided congruency scores used to assess self-judgment and perspective taking performance. The self-judgment "accuracy" score was diminished in AD, and when patients assessed adjectives for self-relevance, they predominantly activated bilateral intraparietal sulci (IPS). Previous studies associated IPS activation with familiarity judgment, which AD patients would use more than recollection when retrieving information to assess self-personality. When taking a third-person perspective, patients activated prefrontal regions (similarly to young volunteers), while elderly controls recruited visual associative areas (also activated by young volunteers). This suggests that mild AD patients relied more on reasoning processes than on visual imagery of autobiographical memories to take their relative's perspective. This strategy may help AD patients to cope with episodic memory impairment even if it does not prevent them from making some mind-reading errors.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Ruby, Perrine; Institut National de la Santé et de la Recherche Médicale - INSERM > ULiège - Centre de Recherches du Cyclotron
Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie - Département des sciences cognitives
D'Argembeau, Arnaud ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Peters, Frédéric; Université de Liège - ULiège > Centre de Recherches du Cyclotron
Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Balteau, Evelyne ; Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ; Université de Liège - ULiège > Centre de recherches du cyclotron > Chimie organique de synthèse
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron
Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron > Département des sciences cliniques-Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Perspective taking to assess self-personality: What's modified in Alzheimer's disease?
F.R.S.-FNRS - Fonds de la Recherche Scientifique ULg - University of Liège BELSPO - Belgian Science Policy Office EC - European Commission
Funding text :
This work was supported by the National Fund for Scientific Research (FNRS), by the University of Liège, by the InterUniversity Attraction Pole P 6/29 (Belgian State-Belgian Science Policy), by the EC-FP6-project DiMI, LSHB-CT- 2005-512146, and by the European Community, which granted P. Ruby a Marie Curie Individual fellowship. AD, EB, FC, and PM are supported by the FNRS.
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