Alzheimers disease; Neuroimaging; short-term recognition memory; verbal working memory; fMRI
Abstract :
[en] Although many studies have shown diminished performance in verbal short-term memory tasks in Alzheimer's disease, few studies have explored the neural correlates of impaired verbal short-term memory in Alzheimer's disease patients. In this fMRI study, we examined alterations in brain activation patterns during a verbal short-term memory recognition task, by differentiating encoding and retrieval phases. Sixteen mild Alzheimer's disease patients and 16 elderly controls were presented with lists of four words followed, after a few seconds, by a probe word. Participants had to judge whether the probe matched one of the items of the memory list. In both groups, the short-term memory task elicited a distributed fronto-parieto-temporal activation that encompassed bilateral inferior frontal, insular, supplementary motor, precentral and postcentral areas, consistent with previous studies of verbal short-term memory in young subjects. Most notably, Alzheimer's disease patients showed reduced activation in several regions during the encoding phase, including the bilateral middle frontal and the left inferior frontal gyri (associated with executive control processes) as well as the transverse temporal gyri (associated with phonological processing). During the recognition phase, we found decreased activation in the left supramarginal gyrus and the right middle frontal gyrus in Alzheimer's disease patients compared with healthy seniors, possibly related to deficits in manipulation and decision processes for phonological information. At the same time, Alzheimer's disease patients showed increased activation in several brain areas, including the left parahippocampus and hippocampus, suggesting that Alzheimer's disease patients may recruit alternative recognition mechanisms when performing a short-term memory task. Overall, our results indicate that Alzheimer's disease patients show differences in the functional networks underlying memory over short delays, mostly in brain areas known to support phonological processing or executive functioning.
Disciplines :
Neurology
Author, co-author :
Peters, Fréderic
Collette, Fabienne ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cognitives > Neuropsychologie - Département des sciences cognitives
Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Majerus, Steve ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
The neural correlates of verbal short-term memory in Alzheimer's disease: an fMRI study.
Publication date :
2009
Journal title :
Brain: a Journal of Neurology
ISSN :
0006-8950
eISSN :
1460-2156
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
132
Issue :
7
Pages :
1833-1846
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] the Interuniversity Attraction Poles Program P6/29 the EC-FP6 project DiMI LSHB-CT-2005-512146 Fonds Léon Fredericq [BE]
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