Article (Scientific journals)
Genetic markers may predict disease behavior in patients with ulcerative colitis.
Roussomoustakaki, M.; Satsangi, J.; Welsh, K. et al.
1997In Gastroenterology, 112 (6), p. 1845-53
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Keywords :
Adolescent; Adult; Aged; Antibodies, Antineutrophil Cytoplasmic/metabolism; Child; Colitis, Ulcerative/genetics; Female; Genetic Markers; Humans; Male; Middle Aged
Abstract :
[en] BACKGROUND & AIMS: Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively. The aim of this study was to test these hypotheses in patients undergoing surgery for their colitis. METHODS: HLA DRB1 and DQB1 genotyping was performed in 99 patients and 472 controls. Genotyping for polymorphisms of genes encoding tumor necrosis factor alpha and IL-1RA was performed in 107 patients and 89 controls. Measurement of antineutrophil cytoplasmic antibody (ANCA) was performed in 72 patients and 58 healthy subjects by fixed neutrophil enzyme-linked immunosorbent assay and indirect immunofluorescence. RESULTS: The DRB1*0103 allele was increased in patients (14.1% vs. 3.2% in controls; P < 1 x 10[-5]). This association was greatest in patients with extensive disease (15.8%; P < 0.0001) or extraintestinal manifestations (22.8%; P < 0.0001): mouth ulcers (25.8%; P < 0.0001), arthritis (27.2%; P < 0.0001), and uveitis (35.7%; P < 0.0001). The DRB1*04 alleles were reduced in patients (P = 0.005). Differences were noted between extensive and distal disease in the frequency of allele 2 of IL-1RA (10.9% in distal vs. 28.6% in extensive; P = 0.01) and allele 2 homozygosity. ANCA was detected in 76.4% of patients. Carriage of IL-1RA allele 2 and tumor necrosis factor 2 allele was increased in ANCA-positive patients. CONCLUSIONS: Genetic markers may predict disease behavior in ulcerative colitis.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Roussomoustakaki, M.
Satsangi, J.
Welsh, K.
Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie - Relations académiques et scientifiques (Médecine)
Fanning, G.
Targan, S.
Landers, C.
Jewell, D. P.
Language :
English
Title :
Genetic markers may predict disease behavior in patients with ulcerative colitis.
Publication date :
1997
Journal title :
Gastroenterology
ISSN :
0016-5085
eISSN :
1528-0012
Publisher :
W.B. Saunders, Philadelphia, United States - Pennsylvania
Volume :
112
Issue :
6
Pages :
1845-53
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 November 2009

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