Immunization and Dermatophytes

[en] PURPOSE OF REVIEW: Despite the availability of effective vaccines for certain animal species, vaccination against dermatophytosis requires improvement and further development in both animals and humans. This review provides an update on the current situation and focuses on recent advances in host-dermatophyte relationships that could have implications for future vaccination against the most prevalent of the fungal diseases. RECENT FINDINGS: Numerous dermatophytic virulence factors have recently been isolated and characterized at the molecular level, notably secreted proteases involved in the invasion of the keratin network. Their precise roles in the different steps of the infectious process and in immunopathogenesis are being studied, while all aspects of the host immune response against dermatophytes, including the innate response, are becoming increasingly documented. In addition, new molecular tools are now available for studying dermatophytes, which will accelerate research on this topic. SUMMARY: The growth of knowledge concerning all aspects of the host-dermatophyte relationship should contribute towards sound strategies for the development of effective and safe vaccines against dermatophytosis.

Disciplines :

Veterinary medicine & animal health
Dermatology

Author, co-author :

Mignon, Bernard ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires

Tabart, Jérémy

Baldo, Aline ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires

Mathy, Anne ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires

Losson, Bertrand ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires

Vermout, Sandy

Language :

English

Title :

Immunization and Dermatophytes

Publication date :

April 2008

Journal title :

Current Opinion in Infectious Diseases

ISSN :

0951-7375

eISSN :

1535-3877

Publisher :

Lippincott Williams & Wilkins, United States - Maryland

Volume :

Issue :

Pages :

134-140

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 February 2010

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