Reference : Common virulence factors and genetic relationships between O18 : K1 : H7 Escherichia ...
Scientific journals : Article
Life sciences : Microbiology
Common virulence factors and genetic relationships between O18 : K1 : H7 Escherichia coli isolates of human and avian origin
Moulin-Schouleur, M. [> > > >]
Schouler, C. [> > > >]
Tailliez, P. [> > > >]
Kao, M. R. [> > > >]
Bree, A. [> > > >]
Germon, P. [> > > >]
Oswald, E. [> > > >]
Mainil, Jacques mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Bactériologie et pathologie des maladies bactériennes >]
Blanco, M. [> > > >]
Blanco, J. [> > > >]
Journal of Clinical Microbiology
Amer Soc Microbiology
Yes (verified by ORBi)
[en] Extraintestinal pathogenic (ExPEC) Escherichia coli strains of serotype 018:K1:H7 are mainly responsible for neonatal meningitis and sepsis in humans and belong to a limited number of closely related clones. The same serotype is also frequently isolated from the extraintestinal lesions of colibacillosis in poultry, but it is not well known to what extent human and avian strains of this particular serotype are related. Twenty-two ExPEC isolates of human origin and 33 isolates of avian origin were compared on the basis of their virulence determinants, lethality for chicks, pulsed-field gel electrophoresis (PFGE) patterns, and classification in the main phylogenetic groups. Both avian and human isolates were lethal for chicks and harbored similar virulence genotypes. A major virulence pattern, identified in 75% of the isolates, was characterized by the presence of F1 variant fimbriae; S fimbriae; IbeA; the aerobactin system; and genomic fragments A9, A12, D1, D7, D10, and D11 and by the absence of P fimbriae, F1C fimbriae, Afa adhesin, and CNF1. All but one of the avian and human isolates also belonged to major phylogenetic group B2. However, various subclonal populations could be distinguished by PFGE in relation to animal species and geographical origin. These results demonstrate that very closely related clones can be recovered from extraintestinal infections in humans and chickens and suggest that avian pathogenic E. coli isolates of serotype 018:K1:H7 are potential human pathogens.

File(s) associated to this reference

Fulltext file(s):

Restricted access
2006-Common virulence factors and genetic relationchips between 018 K1 H7 Escherichia coli.pdfPublisher postprint298.72 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.