Article (Scientific journals)
Functional network antagonism and consciousness
Demertzi, Athina; Kucyi, Aaron; Ponce-Alvarez, Adrián et al.
2022In Network Neuroscience, 6 (4), p. 998-1009
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Keywords :
Applied Mathematics; Artificial Intelligence; Computer Science Applications; General Neuroscience
Abstract :
Spontaneous brain activity changes across states of consciousness. A particular consciousness-mediated configuration is the anticorrelations between the default mode network and other brain regions. What this antagonistic organization implies about consciousness to date remains inconclusive. In this Perspective Article, we propose that anticorrelations are the physiological expression of the concept of segregation, namely the brain’s capacity to show selectivity in the way areas will be functionally connected. We postulate that this effect is mediated by the process of neural inhibition, by regulating global and local inhibitory activity. While recognizing that this effect can also result from other mechanisms, neural inhibition helps the understanding of how network metastability is affected after disrupting local and global neural balance. In combination with relevant theories of consciousness, we suggest that anticorrelations are a physiological prior that can work as a marker of preserved consciousness. We predict that if the brain is not in a state to host anticorrelations, then most likely the individual does not entertain subjective experience. We believe that this link between anticorrelations and the underlying physiology will help not only to comprehend how consciousness happens, but also conceptualize effective interventions for treating consciousness disorders in which anticorrelations seem particularly affected.
Disciplines :
Neurosciences & behavior
Author, co-author :
Demertzi, Athina  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Physiology of Cognition ; Fund for Scientific Research, FNRS, Bruxelles, Belgium
Kucyi, Aaron ;  Department of Psychology, Northeastern University, Boston, MA, USA
Ponce-Alvarez, Adrián ;  Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain
Keliris, Georgios A. ;  Bio-Imaging Lab, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
Whitfield-Gabrieli, Susan;  Department of Psychology, Northeastern University, Boston, MA, USA ; Northeastern University Biomedical Imaging Center (NUBIC), Northeastern University Interdisciplinary Science and Engineering Complex (ISEC), Boston, MA, USA
Deco, Gustavo ;  Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain ; Institució Catalana de la Recerca i Estudis Avançats (ICREA), Barcelona, Spain ; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany ; Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University, Clayton, Melbourne, VIC, Australia
Language :
English
Title :
Functional network antagonism and consciousness
Publication date :
30 June 2022
Journal title :
Network Neuroscience
eISSN :
2472-1751
Publisher :
MIT Press - Journals
Volume :
6
Issue :
4
Pages :
998-1009
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 05 September 2022

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