Article (Scientific journals)
Clonidine and ketanserin both are effective treatment for postanesthetic shivering.
Joris, Jean; Banache, Maryse; Bonnet, Francis et al.
1993In Anesthesiology, 79 (3), p. 532-9
Peer Reviewed verified by ORBi
 

Files


Full Text
221.pdf
Publisher postprint (596.31 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Adult; Anesthesia Recovery Period; Anesthesia, General; Blood Pressure/drug effects/physiology; Clonidine/therapeutic use; Dose-Response Relationship, Drug; Female; Heart Rate/drug effects/physiology; Humans; Ketanserin/therapeutic use; Male; Middle Aged; Shivering/drug effects/physiology; Surgical Procedures, Operative
Abstract :
[en] BACKGROUND: Although meperidine is an effective treatment of postanesthetic shivering, its mechanism of action remains unknown. Investigation of other drugs might help clarify the mechanisms by which shivering can be controlled. Accordingly, we investigated the efficacy of clonidine, an alpha 2-adrenergic agonist, and ketanserin, a 5-hydroxytryptamine antagonist, in treating postanesthetic shivering. METHODS: First, 54 patients shivering after general anesthesia were allocated randomly to receive an intravenous bolus of saline, 150 micrograms clonidine, or 10 mg ketanserin. A second study explored the dose-dependence of clonidine. Forty shivering patients were given saline or clonidine, 37.5, 75, or 150 micrograms. RESULTS: The duration of shivering was significantly shorter in those given clonidine (2.1 +/- 0.9 min) than in the other two groups and shorter in the ketanserin group (4.3 +/- 0.9 min) than in the saline group (12.0 +/- 1.6 min). Clonidine and ketanserin significantly decreased systolic arterial blood pressure when compared to saline. Core rewarming was significantly slower in the clonidine group. In the second study, 37.5 micrograms clonidine was no more effective than saline. Two minutes after treatment, 150 micrograms obliterated shivering in all patients. Five minutes after treatment, all patients given 75 micrograms had stopped shivering. Systolic arterial pressure and heart rate decreased significantly in patients given 75 and 150 micrograms clonidine. CONCLUSIONS: Clonidine (150 micrograms) and ketanserin (10 mg) both are effective treatment for postanesthetic shivering. The effect of clonidine on shivering is dose-dependent: whereas 37.5 micrograms had no effect, 75 micrograms clonidine stopped shivering within 5 min.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Joris, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Banache, Maryse
Bonnet, Francis
Sessler, Daniel I
Lamy, Maurice ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Language :
English
Title :
Clonidine and ketanserin both are effective treatment for postanesthetic shivering.
Publication date :
1993
Journal title :
Anesthesiology
ISSN :
0003-3022
eISSN :
1528-1175
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Volume :
79
Issue :
3
Pages :
532-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 October 2009

Statistics


Number of views
97 (2 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
141
Scopus citations®
without self-citations
118
OpenCitations
 
119

Bibliography


Similar publications



Contact ORBi