Article (Scientific journals)
Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives
Letertre, M. P. M.; Giraudeau, P.; De Tullio, Pascal
2021In Frontiers in Molecular Biosciences, 8
Peer Reviewed verified by ORBi
 

Files


Full Text
fmolb-08-698337.pdf
Publisher postprint (2.84 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Personalized medicine is probably the most promising area being developed in modern medicine. This approach attempts to optimize the therapies and the patient care based on the individual patient characteristics. Its success highly depends on the way the characterization of the disease and its evolution, the patient’s classification, its follow-up and the treatment could be optimized. Thus, personalized medicine must combine innovative tools to measure, integrate and model data. Towards this goal, clinical metabolomics appears as ideally suited to obtain relevant information. Indeed, the metabolomics signature brings crucial insight to stratify patients according to their responses to a pathology and/or a treatment, to provide prognostic and diagnostic biomarkers, and to improve therapeutic outcomes. However, the translation of metabolomics from laboratory studies to clinical practice remains a subsequent challenge. Nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) are the two key platforms for the measurement of the metabolome. NMR has several advantages and features that are essential in clinical metabolomics. Indeed, NMR spectroscopy is inherently very robust, reproducible, unbiased, quantitative, informative at the structural molecular level, requires little sample preparation and reduced data processing. NMR is also well adapted to the measurement of large cohorts, to multi-sites and to longitudinal studies. This review focus on the potential of NMR in the context of clinical metabolomics and personalized medicine. Starting with the current status of NMR-based metabolomics at the clinical level and highlighting its strengths, weaknesses and challenges, this article also explores how, far from the initial “opposition” or “competition”, NMR and MS have been integrated and have demonstrated a great complementarity, in terms of sample classification and biomarker identification. Finally, a perspective discussion provides insight into the current methodological developments that could significantly raise NMR as a more resolutive, sensitive and accessible tool for clinical applications and point-of-care diagnosis. Thanks to these advances, NMR has a strong potential to join the other analytical tools currently used in clinical settings. © Copyright © 2021 Letertre, Giraudeau and de Tullio.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Letertre, M. P. M.;  Université de Nantes, CNRS, CEISAM, UMR 6230, Nantes, France
Giraudeau, P.;  Université de Nantes, CNRS, CEISAM, UMR 6230, Nantes, France
De Tullio, Pascal ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Language :
English
Title :
Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives
Publication date :
2021
Journal title :
Frontiers in Molecular Biosciences
eISSN :
2296-889X
Publisher :
Frontiers Media S.A.
Volume :
8
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 814747 - SUMMIT - Site-specific Ultrasensitive Magnetic resonance of Mixtures for Isotopic Tracking
Funders :
ERC - European Research Council [BE]
EU - European Union [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 28 January 2022

Statistics


Number of views
79 (7 by ULiège)
Number of downloads
5 (5 by ULiège)

Scopus citations®
 
41
Scopus citations®
without self-citations
37
OpenCitations
 
13

Bibliography


Similar publications



Contact ORBi