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19 January 2022
Article (Scientific journals)
Evaluation of the Revogene GBS DS assay performance for the intrapartum screening of group B streptococcus in comparison with intrapartum culture
MEEX, Cécile  ; DEVEY, Anaïs  ; Defêche, Justine  et al.
2021 • In Diagnostic Microbiology and Infectious Disease
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Keywords :
Group B streptococcus; Intrapartum screening; Revogene
Abstract :
[en] Prevention of perinatal Group B Streptococcus (GBS) transmission is crucial in our effort to prevent Earlyonset GBS disease. Here, we established the performance of the Revogene GBS DS assay for the detection of group B streptococcus on intrapartum vaginal samples in a laboratory environment using a prospective noninterventional study design. Intrapartum vaginal swabs were enriched using a selective culture method which served as study reference method. Overall, 119 patients were enrolled with an antenatal and intrapartum Group B Streptococcus colonization prevalence of 12.9% and 11.8%, respectively. Compared to intrapartum culture, the Revogene GBS DS assay had a sensitivity of 92.9% and a specificity of 99.1%, while the antenatal culture displayed a sensitivity 78.6% of and specificity of 96.2%. The Revogene GBS DS assay displayed an acceptable performance according to the European Group B Streptococcus consensus recommendations. Complementary studies in clinical practice are needed to confirm these findings.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
MEEX, Cécile ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire bactériologie
DEVEY, Anaïs ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service d'hématologie biologique et immuno-hématologie
Defêche, Justine ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Pool assistant - biologie clinique
BONTEMS, Sébastien ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire LRS
DESCY, Julie ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire mycobactérie
HAYETTE, Marie-Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique
SACHELI, Rosalie ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire CNR
MELIN, Pierrette ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique
Language :
English
Title :
Evaluation of the Revogene GBS DS assay performance for the intrapartum screening of group B streptococcus in comparison with intrapartum culture
Publication date :
2021
Journal title :
Diagnostic Microbiology and Infectious Disease
ISSN :
0732-8893
Publisher :
Elsevier, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi

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