Group B streptococcus; Intrapartum screening; Revogene
Abstract :
[en] Prevention of perinatal Group B Streptococcus (GBS) transmission is crucial in our effort to prevent Earlyonset GBS disease. Here, we established the performance of the Revogene GBS DS assay for the detection of group B streptococcus on intrapartum vaginal samples in a laboratory environment using a prospective noninterventional study design. Intrapartum vaginal swabs were enriched using a selective culture method which served as study reference method. Overall, 119 patients were enrolled with an antenatal and intrapartum Group B Streptococcus colonization prevalence of 12.9% and 11.8%, respectively. Compared to intrapartum culture, the Revogene GBS DS assay had a sensitivity of 92.9% and a specificity of 99.1%, while the antenatal culture displayed a sensitivity 78.6% of and specificity of 96.2%. The Revogene GBS DS assay displayed an acceptable performance according to the European Group B Streptococcus consensus recommendations.
Complementary studies in clinical practice are needed to confirm these findings.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
MEEX, Cécile ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire bactériologie
DEVEY, Anaïs ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service d'hématologie biologique et immuno-hématologie
Defêche, Justine ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Pool assistant - biologie clinique
BONTEMS, Sébastien ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire LRS
DESCY, Julie ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire mycobactérie
HAYETTE, Marie-Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique
SACHELI, Rosalie ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire CNR
MELIN, Pierrette ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique
Language :
English
Title :
Evaluation of the Revogene GBS DS assay performance for the intrapartum screening of group B streptococcus in comparison with intrapartum culture
