Article (Scientific journals)
Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases
Tachikart, Y.; MALAISE, Olivier; Mumme, M. et al.
2019In Biochemical Pharmacology
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Keywords :
Osteoarthritis; Osteoporosis; Rheumatology; Senescence; Therapies
Abstract :
[en] Over the past years, through in vitro studies and unique animal models, biologists and clinicians have demonstrated that cellular senescence is at the root of numerous age-related chronic diseases including osteoarthritis and osteoporosis. This non-proliferative cellular syndrome can modify other surrounding tissue-resident cells through the establishment of a deleterious catabolic and inflammatory microenvironment. Targeting these deleterious cells through local or systemic seno-therapeutic agent delivery in pre-clinical models improves dramatically clinical signs and extends health span. In this review, we will summarize the current knowledge on cellular senescence, list the different strategies for identifying seno-suppressive therapeutic agents and their translations to rheumatic diseases. © 2019 Elsevier Inc.
Disciplines :
Rheumatology
Author, co-author :
Tachikart, Y. ;  IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France
MALAISE, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de rhumatologie
Mumme, M.;  IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France, Clinic for Orthopedics and Traumatology, University Hospital of Basel, Basel, Switzerland
Jorgensen, C.;  IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France, Service de Rhumatologie, CHU La Peyronie, Montpellier, France
Brondello, J.-M.;  IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France
 These authors have contributed equally to this work.
Language :
English
Title :
Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases
Publication date :
2019
Journal title :
Biochemical Pharmacology
ISSN :
0006-2952
eISSN :
1873-2968
Publisher :
Elsevier Inc.
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 January 2022

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