Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases

[en] Over the past years, through in vitro studies and unique animal models, biologists and clinicians have demonstrated that cellular senescence is at the root of numerous age-related chronic diseases including osteoarthritis and osteoporosis. This non-proliferative cellular syndrome can modify other surrounding tissue-resident cells through the establishment of a deleterious catabolic and inflammatory microenvironment. Targeting these deleterious cells through local or systemic seno-therapeutic agent delivery in pre-clinical models improves dramatically clinical signs and extends health span. In this review, we will summarize the current knowledge on cellular senescence, list the different strategies for identifying seno-suppressive therapeutic agents and their translations to rheumatic diseases. © 2019 Elsevier Inc.

Disciplines :

Rheumatology

Author, co-author :

Tachikart, Y. ^✱; IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France

MALAISE, Olivier ^✱; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de rhumatologie

Mumme, M.; IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France, Clinic for Orthopedics and Traumatology, University Hospital of Basel, Basel, Switzerland

Jorgensen, C.; IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France, Service de Rhumatologie, CHU La Peyronie, Montpellier, France

Brondello, J.-M.; IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases

Publication date :

2019

Journal title :

Biochemical Pharmacology

ISSN :

0006-2952

eISSN :

1873-2968

Publisher :

Elsevier Inc.

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 19 January 2022

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