On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes - Reply to Johnson JD [letter](Esser).pdf
Johnson JD (2021) On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes. Diabetologia 10.1007/s00125-021-05505-4
Esser N, Utzschneider KM, Kahn SE (2020) Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia. Diabetologia 63(10):2007–2021. 10.1007/s00125-020-05245-x DOI: 10.1007/s00125-020-05245-x
Mitrakou A, Kelley D, Mokan M et al (1992) Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326(1):22–29. 10.1056/nejm199201023260104 DOI: 10.1056/nejm199201023260104
Wagner R, Heni M, Tabák AG et al (2021) Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Nat Med. 10.1038/s41591-020-1116-9
Trico D, Natali A, Arslanian S, Mari A, Ferrannini E (2018) Identification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents. JCI Insight 3(24):e124912. 10.1172/jci.insight.124912 DOI: 10.1172/jci.insight.124912
van Vliet S, Koh HE, Patterson BW et al (2020) Obesity Is Associated With Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance. Diabetes 69(10):2112–2119. 10.2337/db20-0377 DOI: 10.2337/db20-0377
RISE Consortium (2018) Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: II. Observations using the oral glucose tolerance test. Diabetes Care 41(8):1707–1716. 10.2337/dc18-0243 DOI: 10.2337/dc18-0243
RISE Consortium (2018) Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: I. Observations using the hyperglycemic clamp. Diabetes Care 41(8):1696–1706. 10.2337/dc18-0244 DOI: 10.2337/dc18-0244
Best JD, Kahn SE, Ader M, Watanabe RM, Ni TC, Bergman RN (1996) Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care 19(9):1018–1030. 10.2337/diacare.19.9.1018 DOI: 10.2337/diacare.19.9.1018
Araújo-Vilar D, García-Estévez DA, Cabezas-Cerrato J (1999) Insulin sensitivity, glucose effectiveness, and insulin secretion in nondiabetic offspring of patients with non-insulin-dependent diabetes mellitus: a cross-sectional study. Metabolism 48(8):978–983. 10.1016/s0026-0495(99)90193-2 DOI: 10.1016/s0026-0495(99)90193-2
Weiss R, Magge SN, Santoro N et al (2015) Glucose effectiveness in obese children: relation to degree of obesity and dysglycemia. Diabetes Care 38(4):689–695. 10.2337/dc14-2183 DOI: 10.2337/dc14-2183
Spreghini N, Cianfarani S, Spreghini MR et al (2019) Oral glucose effectiveness and metabolic risk in obese children and adolescents. Acta Diabetol 56(8):955–962. 10.1007/s00592-019-01303-y DOI: 10.1007/s00592-019-01303-y
Hu S, Lu Y, Tura A, Pacini G, D’Argenio DZ (2021) An analysis of glucose effectiveness in subjects with or without type 2 diabetes via hierarchical modeling. Front Endocrinol (Lausanne) 12:641713. 10.3389/fendo.2021.641713 DOI: 10.3389/fendo.2021.641713
Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR (1992) Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340(8825):925–929. 10.1016/0140-6736(92)92814-v DOI: 10.1016/0140-6736(92)92814-v
Fujimoto WY, Leonetti DL, Kinyoun JL et al (1987) Prevalence of diabetes mellitus and impaired glucose tolerance among second-generation Japanese-American men. Diabetes 36(6):721–729. 10.2337/diab.36.6.721 DOI: 10.2337/diab.36.6.721