Reference : Effects of a Single Opioid Dose on Gastrointestinal Motility in Rabbits (Oryctolagus ...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/267055
Effects of a Single Opioid Dose on Gastrointestinal Motility in Rabbits (Oryctolagus cuniculus): Comparisons among Morphine, Butorphanol, and Tramadol
English
Deflers, Hélène mailto [Université de Liège - ULiège > > FARAH >]
Gandar, Frederic [Université de Liège - ULiège > > FARAH >]
Bolen, Géraldine mailto [Université de Liège - ULiège > Département d'Ens. et de Clinique des Equidés (DCE) > Imagerie médicale des équidés >]
Detilleux, Johann mailto [Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > Génétique quantitative >]
Sandersen, Charlotte mailto [Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Anesthésiologie et réanimation des animaux de compagnie >]
Marlier, Didier mailto [Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Médecine zoologique >]
14-Jan-2022
Veterinary Sciences
Yes (verified by ORBi)
International
2306-7381
[en] Oryctolagus cuniculus ; butorphanol ; morphine ; tramadol ; gastrointestinal motility
[en] The aim of this study was to evaluate and compare the effects of single doses of butorphanol, morphine, and tramadol on gastrointestinal motility in rabbits (Oryctolagus cuniculus) using non-invasive imaging methods, such as radiographic barium follow through and ultrasonographic contraction counts. Time-lapse radiographic and ultrasound examinations were performed before and after a single intramuscular dose of 5 mg kg−1 butorphanol, 10 mg kg−1 morphine, or 10 mg kg−1 tramadol. Pyloric and duodenal contraction counts by ultrasonography and radiographic repletion scores for the stomach and caecum were analysed using a mixed linear model. No significant effect was noted on ultrasound examinations of pyloric and duodenal contractions after administration of an opioid treatment. Morphine had a significant effect on the stomach and the caecum repletion scores, whereas butorphanol had a significant effect only on the caecum repletion score. Tramadol had no significant effect on the stomach or caecum repletion scores. The present findings suggest that a single dose of 5 mg kg−1 butorphanol or 10 mg kg−1 morphine temporarily slows gastrointestinal transit in healthy rabbits, preventing physiological progression of the alimentary bolus without the induction of ileus. In contrast, a single dose of 10 mg kg−1 tramadol has no such effects
http://hdl.handle.net/2268/267055
10.3390/vetsci9010028
https://www.mdpi.com/2306-7381/9/1/28

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