Article (Scientific journals)
Immunological manifestations in type I diabetic children
David, Bianca-Andreea
2012In Roumanian Archives of Microbiology and Immunology
Peer Reviewed verified by ORBi


Full Text
immunological manifestations.pdf
Publisher postprint (4.82 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to


Keywords :
type 1 diabetes mellitus; children; paraoxonase
Abstract :
[en] In the past decade a number of studies suggested that type 1 diabetes mellitus is an oxidative stress influenced disease. Paraoxonase 1 enzyme plays a crucial role in antiatherogenic-antioxidant circle. The aim of our study was to examine the possible differences in paraoxonase 1 enzymatic activities in diabetic children associated other autoimmune diseases versus a control group. Another objective of the study was to determine if there is any difference according to the gender in paraoxonase 1 activities (arylesterase and paraoxonase activities). Paraoxonase 1 activities were determined in 51 diabetic children and 36 healthy controls. In diabetic children we determined also the C-peptide level. The paraoxonase 1 arylesterase activity was lower in diabetic females compared with diabetic males. The level of C-peptide is in an inverse correlation with the years of the disease. The paraoxonase activities have a correlation with the level of insulin antibodies in type I diabetic children. Our data suggest that paraoxonase enzymatic pattern may be different in these two activities. PON1 arylesterase activity may exhibit a tendency to low levels in women in comparison to men. The C-peptide level is a valuable tool in assessing the restant beta cell function.
Disciplines :
Author, co-author :
David, Bianca-Andreea  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Service de pédiatrie
Language :
Title :
Immunological manifestations in type I diabetic children
Publication date :
April 2012
Journal title :
Roumanian Archives of Microbiology and Immunology
Publisher :
Institutul Cantacuzino, Romania
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
The anti-atherogenic role of paraoxonase 1 in children with type 1 diabetes mellitus. Research Grant from University of Medicine and Pharmacy “Iuliu Hatieganu” – Cluj-Napoca – Romania, 22714/3/06.10.2011.
Available on ORBi :
since 10 January 2022


Number of views
47 (1 by ULiège)
Number of downloads
4 (3 by ULiège)

Scopus citations®
Scopus citations®
without self-citations


Similar publications

Contact ORBi