Article (Scientific journals)
Adipocytes Promote Breast Cancer Cell Survival and Migration through Autophagy Activation
Bellanger, Dorinne; Dziagwa, Cléa; Guimaraes, Cyrille et al.
2021In Cancers
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Keywords :
adipose tissue; autophagy; breast cancer
Abstract :
[en] White adipose tissue interacts closely with breast cancers through the secretion of soluble factors such as cytokines, growth factors or fatty acids. However, the molecular mechanisms of these interactions and their roles in cancer progression remain poorly understood. In this study, we investigated the role of fatty acids in the cooperation between adipocytes and breast cancer cells using a co-culture model. We report that adipocytes increase autophagy in breast cancer cells through the acidification of lysosomes, leading to cancer cell survival in nutrient-deprived conditions and to cancer cell migration. Mechanistically, the disturbance of membrane phospholipid composition with a decrease in arachidonic acid content is responsible for autophagy activation in breast cancer cells induced by adipocytes. Therefore, autophagy might be a central cellular mechanism of white adipose tissue interactions with cancer cells and thus participate in cancer progression.
Disciplines :
Oncology
Author, co-author :
Bellanger, Dorinne
Dziagwa, Cléa ;  Université de Liège - ULiège > GIGA Stem Cells - Cancer Signaling
Guimaraes, Cyrille
Pinault, Michelle
Dumas, Jean François
Brisson, Lucie
Language :
English
Title :
Adipocytes Promote Breast Cancer Cell Survival and Migration through Autophagy Activation
Publication date :
03 August 2021
Journal title :
Cancers
eISSN :
2072-6694
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 January 2022

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