The prolactin gene is located on chromosome 6 in humans

Owerbach, D.; Rutter, W. J.; Cooke, N. E.; Martial, Joseph; Shows, T. B.

doi:10.1126/science.7221563

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The prolactin gene is located on chromosome 6 in humans

Owerbach, D.; Rutter, W. J.; Cooke, N. E. et al.

1981 • In Science, 212 (4496), p. 815-6

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/26683

DOI
10.1126/science.7221563

PubMed
7221563

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Keywords :

Animals; *Chromosomes, Human, 6-12 and X; Genes; Growth Hormone/genetics; Humans; Hybrid Cells/physiology; Linkage (Genetics); Mice; Placental Lactogen/genetics; Prolactin/*genetics

Abstract :

[en] The gene for prolactin has been located on chromosome 6 in humans. DNA fragments of 4.8 and 4.0 kilobases containing prolactin gene sequences were identified in human genomic DNA, whereas DNA fragments of 7.4, 3.6, and 3.3 kilobases containing prolactin gene sequences were found in mouse cells. In somatic cell hybrids of human and mouse cells the 7.4-, 3.6-, and 3.3-kilobase mouse fragments were always present, whereas the 4.8- and 4.0-kilobase human fragments were only present when human chromosome 6 was also present. We conclude that the prolactin gene resides on chromosome 6, a different location from those of the genes for the related hormones chorionic somatomammotropin and growth hormone.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Owerbach, D.

Rutter, W. J.

Cooke, N. E.

Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Shows, T. B.

Language :

English

Title :

The prolactin gene is located on chromosome 6 in humans

Publication date :

1981

Journal title :

Science

ISSN :

0036-8075

eISSN :

1095-9203

Publisher :

American Association for the Advancement of Science, Washington, United States - District of Columbia

Volume :

212

Issue :

4496

Pages :

815-6

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 October 2009

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