Adolescent; Adult; Aged; Antibodies, Monoclonal/therapeutic use; Base Sequence; Crohn Disease/genetics/immunology/therapy; DNA Primers/genetics; Female; Genotype; Heterozygote; Homozygote; Humans; Male; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Receptors, IgG/genetics
Abstract :
[en] Recently, it has been shown that FCGR3A-158 gene polymorphism is associated with biological and possibly clinical response to infliximab in Crohn's disease. We further assessed this association in a subset of 344 patients from the large and well-defined cohort of 573 patients with Crohn's disease from the ACCENT I study. No association could be observed between FCGR3A-158 gene polymorphism and the clinical response to infliximab, which was primarily defined as a decrease of >or=70 points in the Crohn's disease activity index or clinical remission (Crohn's disease activity index <150). We did, however, confirm a trend towards a greater decrease in C-reactive protein after infliximab in V/V homozygotes as compared with V/F heterozygotes and F/F homozygotes (-79.4, -76.5, and -64.3%, respectively, at week 6; P=0.085; one-tailed P=0.043). This finding has no immediate clinical impact but may enhance the understanding of the complex mechanisms of action of anti-tumor necrosis factor agents in Crohn's disease.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Louis, Edouard ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie - Relations académiques et scientifiques (Médecine)
Watier, Herve E
Schreiber, Stefan
Hampe, Jochen
Taillard, Francois
Olson, Allan
Thorne, Nicole
Zhang, Hongyan
Colombel, Jean-Frederic
Language :
English
Title :
Polymorphism in IgG Fc receptor gene FCGR3A and response to infliximab in Crohn's disease: a subanalysis of the ACCENT I study.
Publication date :
2006
Journal title :
Pharmacogenetics and Genomics
ISSN :
1744-6872
eISSN :
1744-6880
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
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