Peri-personal space encoding in patients with disorders of consciousness and cognitive-motor dissociation

Brain injury; Disorders of consciousness; Electroencephalography; Motor-cognitive dissociation; Multisensory; Peri-personal space; Article; Acoustic Stimulation; Adult; Aged; Cognition; Consciousness Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Personal Space; Psychomotor Performance; Touch; Young Adult

Abstract :

[en] Behavioral assessments of consciousness based on overt command following cannot differentiate patients with disorders of consciousness (DOC) from those who demonstrate a dissociation between intent/awareness and motor capacity: cognitive motor dissociation (CMD). We argue that delineation of peri-personal space (PPS) – the multisensory-motor space immediately surrounding the body – may differentiate these patients due to its central role in mediating human-environment interactions, and putatively in scaffolding a minimal form of selfhood. In Experiment 1, we determined a normative physiological index of PPS by recording electrophysiological (EEG) responses to tactile, auditory, or audio-tactile stimulation at different distances (5 vs. 75 cm) in healthy volunteers (N = 19). Contrasts between paired (AT) and summed (A + T) responses demonstrated multisensory supra-additivity when AT stimuli were presented near, i.e., within the PPS, and highlighted somatosensory-motor sensors as electrodes of interest. In Experiment 2, we recorded EEG in patients behaviorally diagnosed as DOC or putative CMD (N = 17, 30 sessions). The PPS-measure developed in Experiment 1 was analyzed in relation with both standard clinical diagnosis (i.e., Coma Recovery Scale; CRS-R) and a measure of neural complexity associated with consciousness. Results demonstrated a significant correlation between the PPS measure and neural complexity, but not with the CRS-R, highlighting the added value of the physiological recordings. Further, multisensory processing in PPS was preserved in putative CMD but not in DOC patients. Together, the findings suggest that indexing PPS allows differentiating between groups of patients whom both show overt motor impairments (DOC and CMD) but putatively distinct levels of awareness or motor intent. © 2019

Disciplines :

Neurology

Author, co-author :

Noël, Jean-Paul

Chatelle, Camille ; Université de Liège - ULiège

Perdikis, S.; Center for Neuroprosthetics, School of Engineering, Ecole Polytechnique Federale de Lausanne (EPFL), Geneva, Switzerland, Brain-Computer Interfaces and Neural Engineering Laboratory, School of Computer Science and Electronic Engineering, University of Essex, United Kingdom

Jöhr, J.; Acute Neurorehabilitation Unit, Neurology, Department of and Clinical Neurosciences, University Hospital of Lausanne, Lausanne, Switzerland

Lopes Da Silva, Marina

Ryvlin, P.; Acute Neurorehabilitation Unit, Neurology, Department of and Clinical Neurosciences, University Hospital of Lausanne, Lausanne, Switzerland

De Lucia, M.; Laboratoire de Recherche en Neuroimagerie, Department of Clinical Neurosciences, University Hospital of Lausanne, University of Lausanne, Lausanne, Switzerland

Millán, J. D. R.; Center for Neuroprosthetics, School of Engineering, Ecole Polytechnique Federale de Lausanne (EPFL), Geneva, Switzerland

Diserens, K.; Acute Neurorehabilitation Unit, Neurology, Department of and Clinical Neurosciences, University Hospital of Lausanne, Lausanne, Switzerland

Serino, A.; MySpace Lab, Department of Clinical Neurosciences, University Hospital of Lausanne, University of Lausanne, Lausanne, Switzerland

Language :

English

Title :

Peri-personal space encoding in patients with disorders of consciousness and cognitive-motor dissociation

Publication date :

2019

Journal title :

NeuroImage: Clinical

eISSN :

2213-1582

Publisher :

Elsevier Inc.

Volume :

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

SNF - Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung

Available on ORBi :

since 22 December 2021

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