Medication-overuse headache: a widely recognized entity amidst ongoing debate

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Keywords :

Medication-overuse headache; Nosology; Review; Headache Disorders, Secondary; Humans; Prevalence

Abstract :

[en] Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to high costs and comorbidities. In the Third Edition of the International Classification of Headache Disorders, medication-overuse headache is recognized as a separate secondary entity next to mostly primary headache disorders, although many clinicians see the disease as a sole complication of primary headache disorders. In this review, we explore the historical background of medication-overuse headache, its epidemiology, phenomenology, pathophysiology and treatment options. The review explores relevant unanswered questions and summarizes the current debates in medication-overuse headache. © 2018, The Author(s).

Disciplines :

Neurology

Author, co-author :

Vandenbussche, N.; Headache Group, Department of Basic and Clinical Neuroscience, King’s College London, and NIHR-Wellcome Trust King’s Clinical Research Facility, King’s College Hospital, Denmark Hill, London, SE5 9PJ, United Kingdom

Laterza, D.; Department of Neuroscience, St. Agostino Estense Hospital, University of Modena and Reggio Emilia, via P. Giardini 1355, Modena, 41100, Italy

Lisicki Martinez, Marco ; Université de Liège - ULiège

Lloyd, J.; Headache Research-Wolfson CARD, King’s College London, London, United Kingdom

Lupi, C.; Headache Centre, Careggi University Hospital, Health Sciences Department, University of Florence, Viale Pieraccini 6, Florence, 50139, Italy

Tischler, H.; Department of Neurology, Medical University Innsbruck, Innsbruck, Austria

Toom, K.; Department of Neurology, Tartu University Clinics, Tartu, Estonia, Estonian Headache Society, Tartu, Estonia

Vandervorst, F.; Department Neurology, UZ Brussel, Jette, Belgium

Quintana, S.; Headache Center, Department of Medicine and Surgery, University of Parma, Parma, Italy

Paemeleire, K.; Department of Neurology, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, B-9000, Belgium

Katsarava, Z.; Evangelical Hospital Unna and University of Duisburg-Essen, Duisburg, Germany

Language :

English

Title :

Medication-overuse headache: a widely recognized entity amidst ongoing debate

Publication date :

2018

Journal title :

Journal of Headache and Pain

ISSN :

1129-2369

eISSN :

1129-2377

Publisher :

Springer, New York, United States - New York

Volume :

Issue :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 10 December 2021

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Bibliography

Diener HC, Holle D, Solbach K, Gaul C (2016) Medication-overuse headache: risk factors, pathophysiology and management. Nat Rev Neurol 12:575–583. 10.1038/nrneurol.2016.124
Evers S, Marziniak M (2010) Clinical features, pathophysiology, and treatment of medication-overuse headache. Lancet Neurol 9:391–401. 10.1016/S1474-4422(10)70008-9
Boes CJ, Capobianco DJ (2005) Chronic migraine and medication-overuse headache through the ages. Cephalalgia 25:378–390. 10.1111/j.1468-2982.2005.00868.x
Lennox W (1934) The use of ergotamine tartrate in migraine. N Engl J Med 210:1061–1065
Silfverskiöld B (1947) Gynergen abuse in cases of migraine. Acta Psychi Search results. Acta Psychiatr Neurol 46:281–285
Graham JR (1955) Treatment of migraine. N Engl J Med 253:726–730; contd. https://doi.org/10.1056/NEJM195510272531705
Lippman CW (1955) Characteristic headache resulting from prolonged use of ergot derivatives. J Nerv Ment Dis 121:270–273
Friedman AP, Von Storch TJ (1955) Ergotamine tolerance in patients with migraine. J Am Med Assoc 157:881–884
Peters GA, Horton BT (1951) Headache: with special reference to the excessive use of ergotamine preparations and withdrawal effects. Proc Staff Meet Mayo Clin 26:153–161
Horton B, Peters G (1963) Clinical manifestations of excessive use of ergotamine preparations and Management of Withdrawal Effect: report of 52 cases. Headache J Head Face Pain 2:214–229. 10.1111/j.1526-4610.1963.hed0204214.x
Wörz R, Baar H, Draf W et al (1975) Headache and dependence on mixed analgesic preparations. MMW Munch Med Wochenschr 117:457–462
Worz R (1980) Abuse and paradoxical effects of analgesic drug mixtures. Br J Clin Pharmacol 10:391S–393S. 10.1111/j.1365-2125.1980.tb01828.x
Mathew NT, Stubits E, Nigam MP (1982) Transformation of episodic migraine into daily headache: analysis of factors. Headache J Head Face Pain 22:66–68. 10.1111/j.1526-4610.1982.hed2202066.x
Mathew NT, Reuveni U, Perez F (1987) Transformed or Evolutive migraine. Headache J Head Face Pain 27:102–106. 10.1111/j.1526-4610.1987.hed2702102.x
Headache Classification Committee of the International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache classification Committee of the International Headache Society. Cephalalgia 8(Suppl 7):1–96
Kaube H, May A, Pfaffenrath V (1994) Sumatriptan. BMJ 308:1573–1574
Limmroth V, Kazarawa Z, Fritsche G, Diener HC (1999) Headache after frequent use of serotonin agonists zolmitriptan and naratriptan. Lancet 353:378. 10.1016/S0140-6736(05)74950-3
Limmroth V, Katsarava Z, Fritsche G et al (2002) Features of medication overuse headache following overuse of different acute headache drugs. Neurology 59:1011–1014. 10.1212/WNL.59.7.1011
Silberstein SD, Lipton RB, Solomon S, Mathew NT (1994) Classification of daily and near-daily headaches: proposed revisions to the IHS criteria. Headache 34:1–7
Headache Classification Subcommittee of the International Headache Society (2004) The international classification of headache disorders: 2nd edition. Cephalalgia 24(Suppl 1):9–160
Olesen J, Bousser MG, Diener HC et al (2006) New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 26:742–746. 10.1111/j.1468-2982.2006.01172.x
Headache Classification Committee of the International Headache Society (2018) Headache classification Committee of the International Headache Society (IHS) the international classification of headache disorders, 3rd edition. Cephalalgia 38:1–211. 10.1177/0333102417738202
Manzoni G, Torelli P (2015) Chronic headaches: a clinician’s experience of ICHD3 beta. Neurol Sci 36:51–55. 10.1007/s10072
Tepper S (2012) Medication-overuse headache (MOH). Contin Lifelong Learn Neurol 18:807–822. 10.1007/978-3-319-19911-5_19
Scher AI, Lipton RB, Stewart WF, Bigal M (2010) Patterns of medication use by chronic and episodic headache sufferers in the general population: results from the frequent headache epidemiology study. Cephalalgia 30:321–328. 10.1111/j.1468-2982.2009.01913.x
Bigal ME, Lipton RB (2008) Excessive acute migraine medication use and migraine progression. Neurology 71:1821–1828. 10.1212/01.wnl.0000335946.53860.1d
Katsarava Z, Schneeweiss S, Kurth T et al (2004) Incidence and predictors for chronicity of headache in patients with episodic migraine. Neurology 62:788–790. 10.1212/01.WNL.0000113747.18760.D2
Westergaard ML, Hansen EH, Glümer C et al (2014) Definitions of medication-overuse headache in population-based studies and their implications on prevalence estimates: a systematic review. Cephalalgia 34:409–425. 10.1177/0333102413512033
Ayzenberg I, Katsarava Z, Sborowski A et al (2012) The prevalence of primary headache disorders in Russia: a countrywide survey. Cephalalgia 32:373–381. 10.1177/0333102412438977
Park J-W, Moon H-S, Kim J-M et al (2014) Chronic daily headache in Korea: prevalence, clinical characteristics, medical consultation and management. J Clin Neurol 10:236. 10.3988/jcn.2014.10.3.236
Yu S, Liu R, Zhao G et al (2012) The prevalence and burden of primary headaches in China: a population-based door-to-door survey. Headache 52:582–591. 10.1111/j.1526-4610.2011.02061.x
Zebenigus M, Tekle-Haimanot R, Worku DK et al (2016) The prevalence of primary headache disorders in Ethiopia. J Headache Pain 17:110. 10.1186/s10194-016-0704-z
Mbewe E, Zairemthiama P, Yeh H-H et al (2015) The epidemiology of primary headache disorders in Zambia: a population-based door-to-door survey. J Headache Pain 16:515. 10.1186/s10194-015-0515-7
Da Silva A, Costa EC, Gomes JB et al (2010) Chronic headache and comorbibities: a two-phase, population-based, cross-sectional study. Headache 50:1306–1312. 10.1111/j.1526-4610.2010.01620.x
Westergaard ML, Munksgaard SB, Bendtsen L, Jensen RH (2016) Medication-overuse headache: a perspective review. Ther Adv Drug Saf 7:147–158. 10.1177/2042098616653390
Kristoffersen ES, Lundqvist C (2014) Medication-overuse headache: epidemiology, diagnosis and treatment. Ther Adv Drug Saf 5:87–99. 10.1177/2042098614522683
Global Burden of Disease Study 2013 Collaborators (2015) Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990?2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 386:743–800. 10.1016/S0140
Cheung V, Amoozegar F, Dilli E (2015) Medication overuse headache. Curr Neurol Neurosci Rep 15:509. 10.1007/s11910-014-0509-x
Munksgaard SB, Jensen RH (2014) Medication overuse headache. Headache 54:1251–1257. 10.1111/head.12408
Irimia P, Palma JA, Fernandez-Torron R, Martinez-Vila E (2011) Refractory migraine in a headache clinic population. BMC Neurol 11(1):94. 10.1186/1471-2377-11-94
Wang S-J, Fuh J-L, Liu C-Y et al (2000) Chronic daily headache in Chinese elderly: prevalence, risk factors, and biannual follow-up. Neurology 54:314–319. 10.1212/WNL.54.2.314
Straube A, Pfaffenrath V, Ladwig KH et al (2010) Prevalence of chronic migraine and medication overuse headache in Germany - the German DMKG headache study. Cephalalgia 30:207–213. 10.1111/j.1468-2982.2009.01906.x
Jonsson P, Hedenrud T, Linde M (2011) Epidemiology of medication overuse headache in the general Swedish population. Cephalalgia 31:1015–1022. 10.1177/0333102411410082
Gelfand AA, Goadsby PJ (2014) Medication overuse in children and adolescents. Curr Pain Headache Rep 18:428. 10.1016/j.neuron.2009.10.017.A
Lipton RB, Manack A, Ricci JA et al (2011) Prevalence and burden of chronic migraine in adolescents: results of the chronic daily headache in adolescents study (C-dAS). Headache 51:693–706. 10.1111/j.1526-4610.2011.01885.x
Wiendels NJ, van der Geest MCM, Neven MSAK et al (2005) Chronic daily headache in children and adolescents. Headache J Head Face Pain 45:678–683. 10.1111/j.1526-4610.2005.05137.x
Maffioletti E, Ferro F, Pucci E et al (2015) P035. Headache prevalence and disability among Italian adolescents aged 11-15 years: a population cross-sectional study. J Headache Pain 16:A148. 10.1186/1129-2377-16-S1-A148
Wang S-J, Fuh J-L, Lu S-R, Juang K-D (2006) Chronic daily headache in adolescents. Neurology 66:193–197. 10.1212/WNL.0b013e3181d2b185
Krogh AB, Larsson B, Linde M (2015) Prevalence and disability of headache among Norwegian adolescents: a cross-sectional school-based study. Cephalalgia 35:1181–1191. 10.1177/0333102415573512
Moore AJ, Shevell M (2004) Chronic daily headaches in pediatric neurology practice. J Child Neurol 19:925–929
Prencipe M, Casini AR, Ferretti C et al (2001) Prevalence of headache in an elderly population: attack frequency, disability, and use of medication. J Neurol Neurosurg Psychiatry 70:377–381. 10.1136/jnnp.70.3.377
de Rijk P, Resseguier N, Donnet A (2017) Headache characteristics and clinical features of elderly migraine patients. Headache J Head Face Pain 58(4):525–533. 10.1111/head.13247
Westergaard ML, Glumer C, Hansen EH, Jensen RH (2014) Prevalence of chronic headache with and without medication overuse: associations with socioeconomic position and physical and mental health status. Pain 155:2005–2013. 10.1016/j.pain.2014.07.002
Linde M, Gustavsson A, Stovner LJ et al (2012) The cost of headache disorders in Europe: the Eurolight project. Eur J Neurol 19:703–711. 10.1111/j.1468-1331.2011.03612.x
Steiner TJ (2005) Lifting the burden: the global campaign to reduce the burden of headache worldwide. J Headache Pain 6:373–377. 10.1007/s10194-005-0241-7
Steiner TJ, Stovner LJ, Katsarava Z et al (2014) The impact of headache in Europe: principal results of the Eurolight project. J Headache Pain 15:1–11. 10.1186/1129-2377-15-31
Vos T, Abajobir AA, Abate KH et al (2017) Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the global burden of disease study 2016. Lancet 390:1211–1259. 10.1016/S0140-6736(17)32154-2
Ashina S, Lyngberg A, Jensen RH (2010) Headache characteristics and chronification of migraine and tension-type headache: a population-based study. Cephalalgia 30:943–954. 10.1177/0333102409357958
Thorlund K, Sun-Edelstein C, Druyts E et al (2016) Risk of medication overuse headache across classes of treatments for acute migraine. J Headache Pain 17(1):107. 10.1186/s10194-016-0696-8
Bigal ME, Serrano D, Buse D et al (2008) Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study. Headache 48:1157–1168. 10.1111/j.1526-4610.2008.01217.x
Paemeleire K, Bahra A, Evers S et al (2006) Medication-overuse headache in patients with cluster headache. Neurology 67:109–113. 10.1111/j.1468-2982.2008.01736.x
Paemeleire K, Evers S, Goadsby PJ (2008) Medication overuse headache in patients with cluster headache. Curr Pain Headache Rep 12:122–127
Wilkinson SM, Becker WJ, Heine JA (2001) Opiate use to control bowel motility may induce chronic daily headache in patients with migraine. Headache 41:303–309. 10.1046/j.1526-4610.2001.111006303.x
Bahra A, Walsh M, Menon S, Goadsby PJ (2003) Does chronic daily headache arise de novo in association with regular use of analgesics? Headache 43:179–190. 10.1046/j.1526-4610.2003.03041.x
Hagen K, Albretsen C, Vilming ST et al (2011) A 4-year follow-up of patients with medication-overuse headache previously included in a randomized multicentre study. J Headache Pain 12:315–322. 10.1007/s10194-010-0285-1
Cevoli S, Sancisi E, Grimaldi D et al (2009) Family history for chronic headache and drug overuse as a risk factor for headache chronification. Headache 49:412–418. 10.1111/j.1526-4610.2008.01257.x
Bigal ME, Lipton RB (2007) The differential diagnosis of chronic daily headaches: an algorithm-based approach. J Headache Pain 8:263–272. 10.1007/s10194-007-0418-3
Baumgartner C, Wessely P, Bingöl C et al (1989) Longterm prognosis of analgesic withdrawal in patients with drug-induced headaches. Headache 29:510–514. 10.1111/j.1526-4610.1989.hed2908510.x
Hagen K, Linde M, Steiner TJ et al (2012) Risk factors for medication-overuse headache: an 11-year follow-up study. The Nord-Trøndelag health studies. Pain 153:56–61. 10.1016/j.pain.2011.08.018
Ashina S, Serrano D, Lipton RB et al (2012) Depression and risk of transformation of episodic to chronic migraine. J Headache Pain 13:615–624. 10.1007/s10194-012-0479-9
Sarchielli P, Corbelli I, Messina P et al (2016) Psychopathological comorbidities in medication-overuse headache: a multicentre clinical study. Eur J Neurol 23:85–91. 10.1111/ene.12794
Kristoffersen ES, Straand J, Russell MB, Lundqvist C (2016) Disability, anxiety and depression in patients with medication-overuse headache in primary care - the BIMOH study. Eur J Neurol 23:28–35. 10.1111/ene.12850
Bendtsen L, Munksgaard SB, Tassorelli C et al (2014) Disability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project). Cephalalgia 34:426–433. 10.1177/0333102413515338
Lampl C, Thomas H, Tassorelli C et al (2016) Headache, depression and anxiety: associations in the Eurolight project. J Headache Pain 17(1):59. 10.1186/s10194-016-0649-2
Curone M, Tullo V, Mea E et al (2011) Psychopathological profile of patients with chronic migraine and medication overuse: study and findings in 50 cases. Neurol Sci 32:177–179. 10.1007/s10072-011-0527-2
Cupini LM, Murtas MD, Costa C et al (2009) Obsessive-compulsive disorder and migraine with medication-overuse headache: research submission. Headache 49:1005–1013. 10.1111/j.1526-4610.2009.01457.x
Radat F, Lanteri-Minet M (2010) What is the role of dependence-related behavior in medication-overuse headache? Headache 50:1597–1611. 10.1111/j.1526-4610.2010.01755.x
Galli F, Pozzi G, Frustaci A et al (2011) Differences in the personality profile of medication-overuse headache sufferers and drug addict patients: a comparative study using MMPI-2. Headache 51:1212–1227. 10.1111/j.1526-4610.2011.01978.x
Scher AI, Stewart WF, Ricci JA, Lipton RB (2003) Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 106:81–89. 10.1016/S0304-3959(03)00293-8
Bigal ME, Liberman JN, Lipton RB (2006) Obesity and migraine: a population study. Neurology 66:545–550. 10.1212/01.wnl.0000197218.05284.82
He Z, Dong L, Zhang Y et al (2015) Metabolic syndrome in female migraine patients is associated with medication overuse headache: a clinic-based study in China. Eur J Neurol 22:1228–1234. 10.1111/ene.12732
Westergaard ML, Glümer C, Hansen EH, Jensen RH (2016) Medication overuse, healthy lifestyle behaviour and stress in chronic headache: results from a population-based representative survey. Cephalalgia 36:15–28. 10.1177/0333102415578430
Hershey AD, Powers SW, Nelson TD et al (2009) Obesity in the pediatric headache population: a multicenter study. Headache J Head Face Pain 49:170–177. 10.1111/j.1526-4610.2008.01232.x
Pakalnis A, Kring D (2012) Chronic daily headache, medication overuse, and obesity in children and adolescents. J Child Neurol 27:577–580. 10.1177/0883073811420869
Sancisi E, Cevoli S, Vignatelli L et al (2010) Increased prevalence of sleep disorders in chronic headache: a case-control study. Headache 50:1464–1472. 10.1111/j.1526-4610.2010.01711.x
Srikiatkhachorn A, le Grand SM, Supornsilpchai W, Storer RJ (2014) Pathophysiology of medication overuse headache-an update. Headache J Head Face Pain 54:204–210. 10.1111/head.12224
Schwedt TJ, Chong CD (2017) Medication overuse headache: pathophysiological insights from structural and functional brain MRI research. Headache J Head Face Pain 57(7):1173–1178. 10.1111/head.13037
Lai T, Wang S (2018) Neuroimaging findings in patients with medication overuse headache. Curr Pain Headache Rep 22:1. 10.1007/s11916-018-0661-0
Supornsilpchai W, Maneesri Le Grand S, Srikiatkhachorn A (2010) Cortical hyperexcitability and mechanism of medication-overuse headache. Cephalalgia 30:1101–1109. 10.1177/0333102409355600
Green A, Gu P, De Felice M et al (2014) Increased susceptibility to cortical spreading depression in an animal model of medication-overuse headache. Cephalalgia 34:594–604. 10.1016/j.smim.2015.08.001.Control
Bongsebandhu-Phubhakdi S, Srikiatkhachorn A (2012) Pathophysiology of medication-overuse headache: implications from animal studies. Curr Pain Headache Rep 16:110–115. 10.1007/s11916-011-0234-y
Belanger S, Ma W, Chabot J-G, Quirion R (2002) Expression of calcitonin gene-related peptide, substance P and protein kinase C in cultured dorsal root ganglion neurons following chronic exposure to mu, delta and kappa opiates. Neuroscience 115:441–453. 10.1016/S0306-4522(02)00452-9
De Felice M, Ossipov MH, Wang R et al (2010) Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. Brain 133:2475–2488. 10.1093/brain/awq159
Okada-Ogawa A, Porreca F, Meng ID (2009) Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls (DNIC) in dura-sensitive medullary dorsal horn neurons. J Neurosci 29:15828–15835. 10.3174/ajnr.A1256.Functional
Wanasuntronwong A, Jansri U, Srikiatkhachorn A (2017) Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headache. BMC Neurosci 18:1–12. 10.1186/s12868-016-0326-z
Srikiatkhachorn A, Tarasub N, Govitrapong P (2000) Effect of chronic analgesic exposure on the central serotonin system: a possible mechanism of analgesic abuse headache. Headache 40:343–350. 10.1046/j.1526-4610.2000.00052.x
Tohyama Y, Yamane F, Merid MF, Diksic M (2001) Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C] methyl-L-tryptophan. Eur Neuropsychopharmacol 11:193–202
Dobson CF, Tohyama Y, Diksic M, Hamel E (2004) Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain. Cephalalgia 24:2–11. 10.1111/j.1468-2982.2004.00647.x
Srikiatkhachorn A, Anthony M (1996) Platelet serotonin in patients with analgesic-induced headache. Cephalalgia 16:423–426. 10.1046/j.1468-2982.1996.1606423.x
Cargnin S, Viana M, Sances G et al (2017) A systematic review and critical appraisal of gene polymorphism association studies in medication-overuse headache. Cephalalgia 0:1–13. 10.1177/0333102417728244
Pisanu C, Caproni S, Congiu D et al (2015) HDAC3 role in medication consumption in medication overuse headache patients: a pilot study. Hum Genomics 9:30. 10.1186/s40246-015-0051-1
Terrazzino S, Sances G, Balsamo F et al (2010) Role of 2 common variants of 5HT2A gene in medication overuse headache. Headache 50:1587–1596. 10.1111/j.1526-4610.2010.01757.x
Di Lorenzo C, Sances G, Di Lorenzo G et al (2007) The wolframin His611Arg polymorphism influences medication overuse headache. Neurosci Lett 424:179–184. 10.1016/j.neulet.2007.07.037
Cargnin S, Viana M, Ghiotto N et al (2014) Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy. Eur J Neurol 21:989–995. 10.1111/ene.12424
Cevoli S, Mochi M, Scapoli C et al (2006) A genetic association study of dopamine metabolism-related genes and chronic headache with drug abuse. Eur J Neurol 13:1009–1013. 10.1111/j.1468-1331.2006.01415.x
Di Lorenzo C, Di Lorenzo G, Sances G et al (2009) Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. J Headache Pain 10:349–355. 10.1007/s10194-009-0136-0
Di Lorenzo C, Coppola G, Currà A et al (2012) Cortical response to somatosensory stimulation in medication overuse headache patients is influenced by angiotensin converting enzyme (ACE) I/D genetic polymorphism. Cephalalgia 32:1189–1197. 10.1177/0333102412461890
Woolf CJ (2012) Central sensitization: implications for the diagnosis and treatment of pain. Pain 152:1–31. 10.1016/j.pain.2010.09.030.Central
Coppola G, Curra A, Di Lorenzo C et al (2010) Abnormal cortical responses to somatosensory stimulation in medication-overuse headache. BMC Neurol 10:126. 10.1186/1471-2377-10-126
Curra A, Coppola G, Gorini M et al (2011) Drug-induced changes in cortical inhibition in medication overuse headache. Cephalalgia an Int jounal headache 31:1282–1290. 10.1177/0333102411415877
Munksgaard SB, Bendtsen L, Jensen RH (2013) Modulation of central sensitisation by detoxification in MOH: results of a 12-month detoxification study. Cephalalgia 33:444–453. 10.1177/0333102412475235
Riederer F, Marti M, Luechinger R et al (2012) Grey matter changes associated with medication-overuse headache: correlations with disease related disability and anxiety. World J Biol Psychiatry 13:517–525. 10.3109/15622975.2012.665175
Michels L, Christidi F, Steiger VR et al (2017) Pain modulation is affected differently in medication-overuse headache and chronic myofascial pain - a multimodal MRI study. Cephalalgia 37:764–779. 10.1177/0333102416652625
Schmidt-Wilcke T, Leinisch E, Straube A et al (2005) Gray matter decrease in patients with chronic tension type headache. Neurology 65:1483–1486. 10.1212/01.wnl.0000183067.94400.80
Chanraud S, Di Scala G, Dilharreguy B et al (2014) Brain functional connectivity and morphology changes in medication-overuse headache: clue for dependence-related processes? Cephalalgia 34:605–615. 10.1177/0333102413519514
Ferraro S, Grazzi L, Mandelli ML et al (2012) Pain processing in medication overuse headache: a functional magnetic resonance imaging (FMRI) study. Pain Med 13:255–262. 10.1111/j.1526-4637.2011.01183.x
Ferraro S, Grazzi L, Muffatti R et al (2012) In medication-overuse headache, fMRI shows long-lasting dysfunction in midbrain areas. Headache 52:1520–1534. 10.1111/j.1526-4610.2012.02276.x
Torta DM, Costa T, Luda E et al (2016) Nucleus accumbens functional connectivity discriminates medication-overuse headache. NeuroImage Clin 11:686–693. 10.1016/j.nicl.2016.05.007
Fumal A, Laureys S, Di Clemente L et al (2006) Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain 129:543–550. 10.1093/brain/awh691
Riederer F, Schaer M, Gantenbein AR et al (2017) Cortical alterations in medication-overuse headache. Headache 57:255–265. 10.1111/head.12993
Riederer F, Gantenbein AR, Marti M et al (2013) Decrease of gray matter volume in the midbrain is associated with treatment response in medication-overuse headache: possible influence of orbitofrontal cortex. J Neurosci 33:15343–15349. 10.1523/JNEUROSCI.3804-12.2013
Rapoport AM (2008) Medication overuse headache: awareness, detection and treatment. CNS Drugs 22:995–1004. 10.2165/0023210-200822120-00003%5Cr22123
Rossi P, Di Lorenzo C, Faroni J et al (2006) Advice alone vs. structured detoxification programmes for medication overuse headache: a prospective, randomized, open-label trial in transformed migraine patients with low medical needs. Cephalalgia 26:1097–1105. 10.1111/j.1468-2982.2006.01175.x
Jonsson P, Linde M, Hensing G, Hedenrud T (2012) Sociodemographic differences in medication use, health-care contacts and sickness absence among individuals with medication-overuse headache. J Headache Pain 13:281–290. 10.1007/s10194-012-0432-y
Bekkelund SI, Salvesen R (2002) Patient satisfaction with a neurological specialist consultation for headache. Scand J Prim Health Care 20:157–160. 10.1080/028134302760234609
Negro A, Curto M, Lionetto L et al (2017) A critical evaluation on MOH current treatments. Curr Treat Options Neurol 19:32. 10.1007/s11940-017-0465-2
Jonsson P, Jakobsson A, Hensing G et al (2013) Holding on to the indispensable medication-- a grounded theory on medication use from the perspective of persons with medication overuse headache. J Headache Pain 14:43. 10.1186/1129
Fritsche G, Frettlöh J, Hüppe M et al (2010) Prevention of medication overuse in patients with migraine. Pain 151:404–413. 10.1016/j.pain.2010.07.032
Kristoffersen ES, Straand J, Vetvik KG et al (2015) Brief intervention for medication-overuse headache in primary care. The BIMOH study:a double-blind pragmatic cluster randomised parallel controlled trial. J Neurol Neurosurg Psychiatry 86:505–512. 10.1136/jnnp-2014-308548
Mehuys E, Paemeleire K, Van Hees T et al (2012) Self-medication of regular headache: a community pharmacy-based survey. Eur J Neurol 19:1093–1099. 10.1111/j.1468-1331.2012.03681.x
Hedenrud T, Babic N, Jonsson P (2014) Medication overuse headache: self-perceived and actual knowledge among pharmacy staff. Headache 54:1019–1025. 10.1111/head.12350
Carlsen LN, Westergaard ML, Bisgaard M et al (2017) National awareness campaign to prevent medication-overuse headache in Denmark. Cephalalgia 0:033310241773689. 10.1177/0333102417736898
Louter MA, Robbins MS, Terwindt GM (2017) Medication overuse headache: an ongoing debate. Neurology 89:1206–1207. 10.1212/WNL.0000000000004374
Olesen J (2012) Detoxification for medication overuse headache is the primary task. Cephalalgia 32:420–422. 10.1177/0333102411431309
Zeeberg P, Olesen J, Jensen R (2006) Probable medication-overuse headache: the effect of a 2-month drug-free period. Neurology 66:1894–1898. 10.1212/01.wnl.0000217914.30994.bd
Carlsen LN, Munksgaard SB, Jensen RH, Bendtsen L (2018) Complete detoxification is the most effective treatment of medication-overuse headache: a randomized controlled open-label trial. Cephalalgia 38:225–236. 10.1177/0333102417737779
Evers S, Jensen R, European Federation of Neurological Societies (2011) Treatment of medication overuse headache??Guideline of the EFNS headache panel. Eur J Neurol 18:1115–1121. 10.1111/j.1468
Kennis K, Kernick D, O’Flynn N (2013) Diagnosis and management of headaches in young people and adults: NICE guideline. Br J Gen Pract 63:443–445. 10.3399/bjgp13X670895
Becker W, Findlay T, Moga C et al (2015) Guideline for primary care management of headache in adults. Can Fam physician Médecin Fam Can 61:670–679
Grazzi L, Bussone G (2011) What future for treatment of chronic migraine with medication overuse? Neurol Sci 32:S19–S22. 10.1007/s10072
Katsarava Z, Obermann M (2013) Medication-overuse headache. Curr Opin Neurol 26:276–281. 10.1097/WCO.0b013e328360d596
Rossi P, Faroni JV, Nappi G (2011) Short-term effectiveness of simple advice as a withdrawal strategy in simple and complicated medication overuse headache. Eur J Neurol 18:396–401. 10.1111/j.1468-1331.2010.03157.x
Rossi P, Faroni JV, Tassorelli C, Nappi G (2013) Advice alone versus structured detoxification programmes for complicated medication overuse headache (MOH): a prospective, randomized, open-label trial. J Headache Pain 14:10. 10.1186/1129-2377-14-10
Kristoffersen ES, Straand J, Vetvik KG et al (2016) Brief intervention by general practitioners for medication-overuse headache, follow-up after 6 months: a pragmatic cluster-randomised controlled trial. J Neurol 263:344–353. 10.1007/s00415-015-7975-1
Créac’h C, Frappe P, Cancade M et al (2011) In-patient versus out-patient withdrawal programmes for medication overuse headache: a 2-year randomized trial. Cephalalgia 31:1189–1198. 10.1177/0333102411412088
Weatherall MW, Telzerow AJ, Cittadini E et al (2010) Intravenous aspirin (lysine acetylsalicylate) in the inpatient management of headache. Neurology 75(12):1098–1103. 10.1212/WNL.0b013e3181f39a11
Raskin NH (1986) Repetitive intravenous dihydroergotamine as therapy for intractable migraine. Neurology 36:995–997. 10.1212/WNL.36.7.995
Mathew NT (1987) Amelioration of ergotamine withdrawal symptoms with naproxen. Headache J Head Face Pain 27:130–133. 10.1111/j.1526-4610.1987.hed2703130.x
Probyn K, Bowers H, Caldwell F et al (2017) Prognostic factors for chronic headache. Neurology 89:291–301. 10.1212/WNL.0000000000004112
Nagy AJ, Gandhi S, Bhola R, Goadsby PJ (2011) Intravenous dihydroergotamine for inpatient management of refractory primary headaches. Neurology 77(20):1827–1832. 10.1212/WNL.0b013e3182377dbb
Cevoli S, Giannini G, Favoni V et al (2017) Treatment of withdrawal headache in patients with medication overuse headache: a pilot study. J Headache Pain. 18(1):56. 10.1186/s10194-017-0763-9
de Goffau MJ, Klaver ARE, Willemsen MG et al (2016) The effectiveness of treatments for patients with medication overuse headache; a systematic review and meta-analysis. J Pain 18:615–627. 10.1016/j.jpain.2016.12.005
Zebenholzer K, Thamer M, Wöber C (2012) Quality of life, depression, and anxiety 6 months after inpatient withdrawal in patients with medication overuse headache: an observational study. Clin J Pain 28:284–290. 10.1097/AJP.0b013e3182321d35
Zeeberg P, Olesen J, Jensen R (2005) Efficacy of multidisciplinary treatment in a tertiary referral headache Centre. Cephalalgia 25:1159–1167. 10.1111/j.1468-2982.2005.00980.x
Pijpers JA, Louter MA, De Bruin ME et al (2016) Detoxification in medication-overuse headache, a retrospective controlled follow-up study: does care by a headache nurse lead to cure? Cephalalgia 36:122–130. 10.1177/0333102415583146
Tassorelli C, Jensen R, Allena M et al (2014) A consensus protocol for the management of medication-overuse headache: evaluation in a multicentric, multinational study. Cephalalgia 34:645–655. 10.1177/0333102414521508
Rossi P, Jensen R, Nappi G, Allena M (2009) A narrative review on the management of medication overuse headache: the steep road from experience to evidence. J Headache Pain 10:407–417. 10.1007/s10194-009-0159-6
Chiang C-C, Schwedt TJ, Wang S-J, Dodick DW (2016) Treatment of medication-overuse headache: a systematic review. Cephalalgia 36:371–386. 10.1177/0333102415593088
Martelletti P (2018) The journey from genetic predisposition to medication overuse headache to its acquisition as sequela of chronic migraine. J Headache Pain 19:2. 10.1186/s10194-017-0830-2
Probyn K, Bowers H, Caldwell F et al (2017) Prognostic factors for chronic headache: a systematic review. Neurology 89:291–301
Hagen K, Jensen R, Bøe MG, Stovner LJ (2010) Medication overuse headache: a critical review of end points in recent follow-up studies. J Headache Pain 11:373–377. 10.1007/s10194-010-0221-4
Diener HC, Dichgans J, Scholz E et al (1989) Analgesic-induced chronic headache: long-term results of withdrawal therapy. J Neurol 236:9–14. 10.1007/BF00314210
Suhr B, Evers S, Bauer B et al (1999) Drug-induced headache: long-term results of stationary versus ambulatory withdrawal therapy. Cephalalgia 19:44–49
Schnider P, Aull S, Baumgartner C et al (1996) Long-term outcome of patients with headache and drug abuse after inpatient withdrawal: five-year follow-up. Cephalalgia 16:481–485
Fritsche G, Eberl A, Katsarava Z et al (2001) Drug-induced headache: long-term follow-up of withdrawal therapy and persistence of drug misuse. Eur Neurol 45:229–235. 10.1159/000052134
Grazzi L, Andrasik F, D’Amico D et al (2002) Behavioral and pharmacologic treatment of transformed migraine with analgesic overuse: outcome at 3 years. Headache 42:483–490. 10.1046/j.1526-4610.2002.02123.x
Zidverc-Trajkovic J, Pekmezovic T, Jovanovic Z et al (2007) Medication overuse headache: clinical features predicting treatment outcome at 1-year follow-up. Cephalalgia 27:1219–1225. 10.1111/j.1468-2982.2007.01432.x
Bigal ME, Rapoport AM, Sheftell FD et al (2004) Transformed migraine and medication overuse in a tertiary headache Centre--clinical characteristics and treatment outcomes. Cephalalgia an Int J headache 24:483–490. 10.1111/j.1468-2982.2004.00691.x
Sances G, Galli F, Anastasi S et al (2010) Medication-overuse headache and personality: a controlled study by means of the MMPI-2: research submission. Headache 50:198–209. 10.1111/j.1526-4610.2009.01593.x
Bøe MG, Salvesen R, Mygland Å (2009) Chronic daily headache with medication overuse: predictors of outcome 1 year after withdrawal therapy. Eur J Neurol 16:705–712. 10.1111/j.1468-1331.2009.02571.x
Bøe MG, Thortveit E, Vatne A, Mygland Å (2017) Chronic headache with medication overuse: long-term prognosis after withdrawal therapy. Cephalalgia 37:1215–1221. 10.1177/0333102416672493
Zidverc-Trajkovic JJ, Pekmezovic T, Jovanovic Z et al (2016) Long-term predictors of remission in patients treated for medication-overuse headache at a specialized headache center: a prospective cohort study. Cephalalgia 0:1–9. 10.1177/0333102416683918
Evers S, Suhr B, Bauer B et al (1999) A retrospective long-term analysis of the epidemiology and features of drug-induced headache. J Neurol 246:802–809. 10.1007/s004150050458
Pini L-A, Cicero A, Sandrini M (2001) Long-term follow-up of patients treated for chronic headache with analgesic overuse. Cephalalgia 21:878–883. 10.1046/j.1468-2982.2001.00288.x
Tribl GG, Schnider P, Wöber C et al (2001) Are there predictive factors for long-term outcome after withdrawal in drug-induced chronic daily headache? Cephalalgia 21:691–696
Katsarava Z, Muessig M, Dzagnidze A et al (2005) Medication overuse headache: rates and predictors for relapse in a 4-year prospective study. Cephalalgia 25:12–15. 10.1111/j.1468-2982.2004.00789.x
Fontanillas N, Colás R, Muñoz P et al (2010) Long-term evolution of chronic daily headache with medication overuse in the general population. Headache 50:981–988. 10.1111/j.1526-4610.2010.01629.x
Zeeberg P, Olesen J, Jensen R (2006) Discontinuation of medication overuse in headache patients: recovery of therapeutic responsiveness. Cephalalgia 26:1192–1198. 10.1111/j.1468-2982.2006.01190.x
Katsarava Z, Limmroth V, Finke M et al (2003) Rates and predictors for relapse in medication overuse headache: a 1-year prospective study. Neurology 60:1682–1683
Tfelt-Hansen P, Krabbe AÆ (1981) Ergotamine abuse. Do patients benefit from withdrawal? Cephalalgia 1:29–32. 10.1111/j.1468-2982.1981.tb00005.x
Sances G, Ghiotto N, Galli F et al (2010) Risk factors in medication-overuse headache: a 1-year follow-up study (care II protocol). Cephalalgia 30:329–336. 10.1111/j.1468-2982.2009.01934.x
Jensen RH, Bendtsen L (2008) Medication overuse headache in Scandinavia. Cephalalgia 28:1237–1239
Serrano D, Lipton RB, Scher AI et al (2017) Fluctuations in episodic and chronic migraine status over the course of 1 year: implications for diagnosis, treatment and clinical trial design. J Headache Pain 18:101. 10.1186/s10194-017-0787-1
Scher AI, Rizzoli PB, Loder EW (2017) Medication overuse headache an entrenched idea in need of scrutiny. Neurology 89:1296–1304. 10.1212/WNL.0000000000004371
Solomon M, Nahas SJ, Segal JZ, Young WB (2011) Medication adaptation headache. Cephalalgia 31:515–517. 10.1177/0333102410387678