Article (Scientific journals)
Erythroferrone and hepcidin as mediators between erythropoiesis and iron metabolism during allogeneic hematopoietic stem cell transplant.
PIROTTE, Michelle; Fillet, Marianne; SEIDEL, Laurence et al.
2021In American Journal of Hematology, 96 (10), p. 1275-1286
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Keywords :
Adult; Aged; Erythropoiesis/drug effects; Erythropoietin/therapeutic use; Female; Hematopoietic Stem Cell Transplantation; Hepcidins/blood/metabolism; Humans; Iron/blood/metabolism; Male; Middle Aged; Peptide Hormones/blood/metabolism; Transplantation, Homologous
Abstract :
[en] Hematopoietic cell transplantation (HCT) brings important alterations in erythropoiesis and iron metabolism. Hepcidin, which regulates iron metabolism, increases in iron overload or inflammation and decreases with iron deficiency or activated erythropoiesis. Erythroferrone (ERFE) is the erythroid regulator of hepcidin. We investigated erythropoiesis and iron metabolism after allogeneic HCT in 70 patients randomized between erythropoietin (EPO) treatment or no EPO, by serially measuring hepcidin, ERFE, CRP (inflammation), soluble transferrin receptor (sTfR, erythropoiesis), serum iron and transferrin saturation (Tsat; iron for erythropoiesis) and ferritin (iron stores). We identified biological and clinical factors associated with serum hepcidin and ERFE levels. Serum ERFE correlated overall with sTfR and reticulocytes and inversely with hepcidin. Erythroferrone paralleled sTfR levels, dropping during conditioning and recovering with engraftment. Inversely, hepcidin peaked after conditioning and decreased during engraftment. Erythroferrone and hepcidin were not significantly different with or without EPO. Multivariate analyses showed that the major determinant of ERFE was erythropoiesis (sTfR, reticulocytes or serum Epo). Pretransplant hepcidin was associated with previous RBC transfusions and ferritin. After transplantation, the major determinants of hepcidin were iron status (ferritin at all time points and Tsat at day 56) and erythropoiesis (sTfR or reticulocytes or ERFE), while the impact of inflammation was less clear and clinical parameters had no detectable influence. Hepcidin remained significantly higher in patients with high compared to low pretransplant ferritin. After allogeneic HCT with or without EPO therapy, significant alterations of hepcidin occur between pretransplant and day 180, in correlation with iron status and inversely with erythroid ERFE.
Disciplines :
Hematology
Author, co-author :
PIROTTE, Michelle ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'hématologie clinique
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
SEIDEL, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur d'appui à la recherche clinique et biostatistique
JASPERS, Aurélie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'hématologie clinique
Baron, Frédéric  ;  Université de Liège - ULiège > GIGA I3 - Hematology
Beguin, Yves  ;  Université de Liège - ULiège > Département des sciences cliniques > Hématologie
Language :
English
Title :
Erythroferrone and hepcidin as mediators between erythropoiesis and iron metabolism during allogeneic hematopoietic stem cell transplant.
Publication date :
2021
Journal title :
American Journal of Hematology
ISSN :
0361-8609
eISSN :
1096-8652
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Volume :
96
Issue :
10
Pages :
1275-1286
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© 2021 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.
Available on ORBi :
since 09 December 2021

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