Article (Scientific journals)
Treatment of patients with newly diagnosed metastatic hormone sensitive prostate cancer (mHSPC) in Belgium: a real world data analysis.
Lambert, E.; Hollebosch, S.; van Praet, C. et al.
2021In Acta Clinica Belgica, p. 1-9
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Keywords :
Abiraterone acetate; androgen deprivation therapy; docetaxel; metastatic hormone sensitive prostate cancer
Abstract :
[en] INTRODUCTION: Abiraterone acetate + prednisone (AAP) and docetaxel have proven their efficacy in the treatment of patients with newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC) in clinical trials. However, real-world data are scarce. The goal of this study is to evaluate real-world data on the efficacy and safety of these therapies in mHSPC patients. PATIENTS AND METHODS: Records of 93 patients from 21 different centres were retrospectively reviewed. Primary and secondary endpoints were radiographic and PSA progression-free survival (RPFS - PSA-PFS) and cancer specific and overall survival (CSS - OS), respectively. Adverse events (AEs) were evaluated according to the Common Terminology Criteria for Adverse Events version 5.0. Differences in oncological outcome and AEs were evaluated between three treatment groups: ADT only (N=26) - ADT + AAP (N=48) - ADT + docetaxel (N=19). Survival analysis was performed using Kaplan-Meier statistics. RESULTS: Median RPFS was 13 months (95% confidence interval [CI]: 9-17) for ADT only, 21 months (95% CI: 19-23) for ADT + AAP and 12 months (95% CI: 11-14) for ADT + docetaxel (p = 0.004). The 1-year PSA-PFS, CSS and OS were 73.5%, 90.7% and 88.7%, respectively, with no significant differences between the three groups. Adverse events of grade 3 or higher were not observed more frequently. CONCLUSION: Retrospective real-world data show a significantly longer RPFS for mHSPC patients treated with ADT + AAP compared to ADT only or ADT + docetaxel at short-term follow-up. This can aid in counselling of mHSPC patients in daily clinical practice.
Disciplines :
Oncology
Author, co-author :
Lambert, E.
Hollebosch, S.
van Praet, C.
Van Bruwaene, S.
Duck, L.
De Roock, W.
van Wambeke, S.
Ghysel, C.
Ameye, F.
Schatteman, P.
Vandenbroucke, F.
Sautois, Brieuc  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Baekelandt, F.
Ost, D.
Fransis, K.
Filleul, B.
Remondo, C.
Wynendaele, W.
Bamelis, B.
Logghe, P.
Vergauwe, E.
Denies, E.
Joniau, S.
Lumen, N.
More authors (14 more) Less
Language :
English
Title :
Treatment of patients with newly diagnosed metastatic hormone sensitive prostate cancer (mHSPC) in Belgium: a real world data analysis.
Publication date :
2021
Journal title :
Acta Clinica Belgica
ISSN :
1784-3286
eISSN :
2295-3337
Publisher :
Taylor & Francis, United Kingdom
Pages :
1-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 December 2021

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