Article (Scientific journals)
Regular Dietary Intake of Palmitate Causes Vascular and Valvular Calcification in a Rabbit Model.
Donis, Nathalie; Jiang, Zheshen; D'Emal, Céline et al.
2021In Frontiers in Cardiovascular Medicine, 8, p. 692184
Peer Reviewed verified by ORBi


Full Text
Donis et al_2021_fcvm-08-692184.pdf
Publisher postprint (4.74 MB)

All documents in ORBi are protected by a user license.

Send to


Keywords :
aortic valve calcification; blood fatty acids; nutrition; palmitate; vascular calcification
Abstract :
[en] Aims: Palmitic acid (PA) and oleic acid (OA) are two main dietary fatty acids. Dietary intake of PA has been associated with cardiovascular disease risk, and the effect of OA remains uncertain. Our study aimed to assess the effect of a short-term intake of lard, as source of PA and OA, on aorta and aortic valve. Methods and Results: Rabbits were fed with two lard-enriched diets, containing either elevated levels of PA or of both PA and OA as compared to chow diet. After 16 weeks of each diet, calcification was observed in the aortic intima and in the aortic valve. The extent of calcification did not differ between the two diets. In contrast, rabbits fed chow diet did not develop any calcification. In blood, PA enrichment resulted in decreased lymphocyte and monocyte counts and increased levels of hemoglobin and haematocrit. Levels of the calcification inhibitor fetuin-A were also diminished, whereas creatinine levels were raised. Of note, none of the diets changed cholesterol levels in LDL or HDL. Comprehensive quantitative lipidomics analysis identified diet-related changes in plasma lipids. Dietary PA enrichment led to a drop of polyunsaturated fatty acids (PUFA), in particular of linoleic acid in cholesteryl esters, triglycerides and diacylglycerols (DAG). Ratios of PA to 18-carbon PUFA in DAG were positively correlated with the extent of aortic valve calcification, and inversely with monocyte counts. PA content in blood correlated with aorta calcification. Conclusions: Regular dietary PA intake induces vascular and valvular calcification independently of traditional risk factors. Our findings raise awareness about PA-rich food consumption and its potential deleterious effect on cardiovascular health.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Donis, Nathalie ;  Université de Liège - ULiège > GIGA
Jiang, Zheshen ;  Université de Liège - ULiège > GIGA Cardiovascular Sciences - Cardiology
D'Emal, Céline 
DULGHERU, Raluca Elena 
Giera, Martin
Blomberg, Niek
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Nchimi Longang, Alain 
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Oury, Cécile  ;  Université de Liège - ULiège > GIGA Cardiovascular Sciences - Cardiology
Language :
Title :
Regular Dietary Intake of Palmitate Causes Vascular and Valvular Calcification in a Rabbit Model.
Publication date :
Journal title :
Frontiers in Cardiovascular Medicine
Publisher :
Frontiers Research Foundation, Lausanne, Switzerland
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2021 Donis, Jiang, D'Emal, Dulgheru, Giera, Blomberg, Delvenne, Nchimi, Lancellotti and Oury.
Available on ORBi :
since 23 November 2021


Number of views
84 (11 by ULiège)
Number of downloads
58 (5 by ULiège)

Scopus citations®
Scopus citations®
without self-citations


Similar publications

Contact ORBi