Article (Scientific journals)
New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments.
Brichant, Géraldine; Laraki, Ines; Henry, Laurie et al.
2021In International Journal of Molecular Sciences, 22 (19)
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Keywords :
Animals; Drug Delivery Systems; Endometriosis/drug therapy/metabolism/pathology; Female; Humans; RNA, Untranslated/metabolism; angiogenesis; apoptosis; cell migration; cell proliferation; endometriosis; fibrosis; inflammation; non-coding RNA; stem cells
Abstract :
[en] Endometriosis is defined as endometrial-like tissue outside the uterine cavity. It is a chronic inflammatory estrogen-dependent disease causing pain and infertility in about 10% of women of reproductive age. Treatment nowadays consists of medical and surgical therapies. Medical treatments are based on painkillers and hormonal treatments. To date, none of the medical treatments have been able to cure the disease and symptoms recur as soon as the medication is stopped. The development of new biomedical targets, aiming at the cellular and molecular mechanisms responsible for endometriosis, is needed. This article summarizes the most recent medications under investigation in endometriosis treatment with an emphasis on non-coding RNAs that are emerging as key players in several human diseases, including cancer and endometriosis.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Brichant, Géraldine ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Laraki, Ines 
Henry, Laurie  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Service de gynécologie-obstétrique (CHR)
Munaut, Carine  ;  Université de Liège - ULiège > GIGA Cancer - Tumours and development biology
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments.
Publication date :
2021
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
22
Issue :
19
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 November 2021

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