[en] Organic nanoparticles made out of biodegradable and biocompatible materials have attracted increased attention in the therapeutic and diagnostic fields. In this study, we attempted to explore a new radiolabelling chelating free strategy for biodegradable sphingomyelin nanometric emulsions with fluorine-18 (18F), a radioisotope regularly used in clinic. [18F]fluoride was produced by the cyclotron and was incorporated into 4-[18F]fluorobenzamido-N-ethylmaleimide ([18F]FBEM), which was coupled next to the emulsions previously functionalized with a thiol group, via inclusion of either a thiol-PEG-lipid (SH-PEG12-C18), or a peptide-PEG-lipid (Cys-Pro-IleGlu-Asp-Arg-Pro-Met-Cys-PEG8-C18) derivative. Radiolabelled emulsions were obtained in a rapid and efficient fashion through facile-conjugated chemistry without the use of organic solvents, and characterized in terms of size, polydispersity, surface charge, pH, and osmolarity. PET imaging and biodistribution studies in BALB/c mice allowed obtaining the pharmacokinetics of the radiolabelled emulsions and determining the clearance pathways. Altogether, we confirmed the potential of this new technique for the radiolabelling of lipid-based drug nanosystems for application in PET imaging diagnosis.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Chemistry
Author, co-author :
Nagachinta, Surasa ; Université de Liège - ULiège > GIGA CRC In vivo Imaging
Becker, Guillaume ; Université de Liège - ULiège > Département de Psychologie > Département de Psychologie
Dammicco, Sylvestre ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Radiochemistry
Serrano Navacerrada, Maria Elisa
LEROI, Natacha ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire Cytogénétique
Bahri, Mohamed Ali ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Plenevaux, Alain ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Preclinical Imaging
Lemaire, Christian ; Université de Liège - ULiège > CRC In vivo Imaging-Radiochemistry
Lopez, Rafael
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
de la Fuente, Maria
Language :
English
Title :
Radiolabelling of lipid-based nanocarriers with fluorine-18 for in vivo tracking by PET.
EACEA - European Education and Culture Executive Agency FEDER - Federación Española de Enfermedades Raras F.R.S.-FNRS - Fonds de la Recherche Scientifique
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