Article (Scientific journals)
An exclusion approach for addressing partial volume artifacts with quantititive computed tomography-based finite element modeling of the proximal tibia
Kalajahi, S. M. H.; Nazemi, Sayed Majid; Johnston, J. D.
2020In Medical Engineering and Physics, 76, p. 95-100
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Keywords :
Finite element modeling; Partial volume artifacts; Proximal tibia; Quantitative computed tomography; Voxel exclusion; Bone; Computerized tomography; Stiffness; Exclusion algorithms; Partial volumes; Quantitative computed tomographies; Standard procedures; Stiffness prediction; Structural stiffness; Finite element method; Article
Abstract :
[en] Introduction: Quantitative computed tomography based finite element modeling (QCT-FE) has potential to clarify the role of subchondral bone stiffness in osteoarthritis. The limited spatial resolution of clinical QCT systems, however, results in partial volume (PV) artifacts and low contrast between cortical and trabecular bone, which adversely affects the accuracy of QCT-FE models. The objective of this research was to evaluate the agreement between stiffness predictions offered by QCT-FE models of proximal tibial subchondral bone (constructed with and without a new voxel-exclusion algorithm) with experimentally-derived local subchondral bone structural stiffness. Methods: Thirteen proximal tibial compartments were obtained and imaged using QCT. Two types of QCT-FE models were developed: (1) standard model, which employed the standard procedure for QCT-FE modeling; and (2) “voxel exclusion (VE)” model, which addressed PV artifacts by excluding low density voxels during the material mapping stage of construction. We assessed agreement between QCT-FE stiffness estimates (using standard and VE approaches) with experimental stiffness by reporting predicted variance from linear regression and mean bias with 95% Limits of Agreement (LOA). Results: The standard and VE models explained 81% and 84% of the variance in experimentally measured stiffness, respectively. The standard model showed a mean bias of -268 N/mm (LOA -1210 to 679 N/mm); the VE model showed a mean bias of +59 N/mm (LOA -762 to 910 N/mm). Interpretation: The VE model explained more variance in subchondral bone stiffness with less bias. Our findings indicate that the VE method has potential to improve QCT-FE models of bone affected by PV artifacts. © 2019
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Kalajahi, S. M. H.;  Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada
Nazemi, Sayed Majid ;  Université de Liège - ULg
Johnston, J. D.;  Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada
Language :
English
Title :
An exclusion approach for addressing partial volume artifacts with quantititive computed tomography-based finite element modeling of the proximal tibia
Publication date :
2020
Journal title :
Medical Engineering and Physics
ISSN :
1350-4533
eISSN :
1873-4030
Publisher :
Elsevier, Oxford, United Kingdom
Volume :
76
Pages :
95-100
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
H03-70308; Natural Sciences and Engineering Research Council of Canada, NSERC
Available on ORBi :
since 06 November 2021

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