Article (Scientific journals)
A postural tremor highly responsive to transcranial cerebello-cerebral DCS in ARCA3
Bodranghien, F.; Oulad Ben Taib, N.; VAN MALDERGEM, Lionel et al.
2017In Frontiers in Neurology, 8 (MAR)
Peer Reviewed verified by ORBi
 

Files


Full Text
fneur-08-00071.pdf
Publisher postprint (1.71 MB)
Download

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.


All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
ANO10; Cerebellar ataxia; Purkinje neurons; Transcranial direct current stimulation; Tremor; Article
Abstract :
[en] Background and objectives: Cerebellar ataxias are disabling disorders that impact the quality of life of patients. In many cases, an effective treatment is missing. Despite the increasing knowledge on the pathogenesis of cerebellar disorders including genetic aspects, there is currently a gap in the therapeutical management of cerebellar deficits. Cerebellar ataxia associated with ANO10 mutation (ARCA3) presents a disabling cerebellar syndrome. The aim of this study is to report a patient with a marked postural tremor responding to transcranial cerebello-cerebral direct current stimulation (tCCDCS). Methods: We applied tCCDCS using anodal stimulation over the cerebellum with a return electrode on the contralateral motor cortex. We performed a clinical rating, accelerometry studies, and recordings of voluntary movements at baseline, after sham, and after active tCCDCS. Results: A dramatic response of postural tremor was observed after tCCDCS, with a major drop of the power spectral density to 26.12% of basal values. Discussion: The postural tremor of cerebellar ataxia associated with ANO10 mutation was highly responsive to tCCDCS in our patient. This case illustrates that tCCDCS is a novel therapeutic option in the treatment of cerebellar deficits and might represent a promising tool to reduce tremor in ARCA3. © 2017 Bodranghien, Oulad Ben Taib, Van Maldergem and Manto.
Disciplines :
Genetics & genetic processes
Neurology
Author, co-author :
Bodranghien, F.;  Unité d'Etude du Mouvement-GRIM, FNRS, ULB-Erasme, Bruxelles, Belgium
Oulad Ben Taib, N.;  Service de Neurochirurgie, ULB-Erasme, Bruxelles, Belgium, Service de Neurochirurgie, CHU-StPierre, Bruxelles, Belgium
VAN MALDERGEM, Lionel ;  Université de Liège - ULg
Manto, M.;  Unité d'Etude du Mouvement-GRIM, FNRS, ULB-Erasme, Bruxelles, Belgium, Service des Neurosciences, UMons, Mons, Belgium
Language :
English
Title :
A postural tremor highly responsive to transcranial cerebello-cerebral DCS in ARCA3
Publication date :
2017
Journal title :
Frontiers in Neurology
eISSN :
1664-2295
Publisher :
Frontiers Media S.A., Switzerland
Volume :
8
Issue :
MAR
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 November 2021

Statistics


Number of views
28 (2 by ULiège)
Number of downloads
25 (2 by ULiège)

Scopus citations®
 
26
Scopus citations®
without self-citations
21
OpenCitations
 
24

Bibliography


Similar publications



Contact ORBi