Quantitative proteomics reveals tissue-specific toxic mechanisms for acute hydrogen sulfide-induced injury of diverse organs in pig

Liu, Zhen; Chen, L.; Gao, X.; Zou, R.; Meng, Q.; Fu, Q.; Xie, Y.; Miao, Q.; Chen, L.; Tang, X.; Zhang, S.; Zhang, HF; Schroyen, Martine

doi:10.1016/j.scitotenv.2021.150365

Article (Scientific journals)

Quantitative proteomics reveals tissue-specific toxic mechanisms for acute hydrogen sulfide-induced injury of diverse organs in pig

Liu, Zhen; Chen, L.; Gao, X. et al.

2022 • In Science of the Total Environment, 806

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/264554

DOI
10.1016/j.scitotenv.2021.150365

PubMed
34555611

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Keywords :

Acute exposure; H2S; Inflammatory injury; Multi-organ injury; Porcine; TMT-based proteomics; Biological organs; Cell death; Hyaluronic acid; Hydrogen sulfide; Mammals; Metabolism; Molecular biology; Proteins; Respiratory system; Tissue; Molecular pathways; Organ injuries; Quantitative proteomics; Tissue specifics; TMT-based proteomic; Toxic gas; Sulfur determination

Abstract :

[en] Hydrogen sulfide (H2S) is a highly toxic gas in many environmental and occupational places. It can induce multiple organ injuries particularly in lung, trachea and liver, but the relevant mechanisms remain poorly understood. In this study, we used a TMT-based discovery proteomics to identify key proteins and correlated molecular pathways involved in the pathogenesis of acute H2S-induced toxicity in porcine lung, trachea and liver tissues. Pigs were subjected to acute inhalation exposure of up to 250 ppm of H2S for 5 h for the first time. Changes in hematology and biochemical indexes, serum inflammatory cytokines and histopathology demonstrated that acute H2S exposure induced organs inflammatory injury and dysfunction in the porcine lung, trachea and liver. The proteomic data showed 51, 99 and 84 proteins that were significantly altered in lung, trachea and liver, respectively. Gene ontology (GO) annotation, KEGG pathway and protein-protein interaction (PPI) network analysis revealed that acute H2S exposure affected the three organs via different mechanisms that were relatively similar between lung and trachea. Further analysis showed that acute H2S exposure caused inflammatory damages in the porcine lung and trachea through activating complement and coagulation cascades, and regulating the hyaluronan metabolic process. Whereas antigen presentation was found in the lung but oxidative stress and cell apoptosis was observed exclusively in the trachea. In the liver, an induced dysfunction was associated with protein processing in the endoplasmic reticulum and lipid metabolism. Further validation of some H2S responsive proteins using western blotting indicated that our proteomics data were highly reliable. Collectively, these findings provide insight into toxic molecular mechanisms that could potentially be targeted for therapeutic intervention for acute H2S intoxication. © 2021

Disciplines :

Agriculture & agronomy

Author, co-author :

Liu, Zhen ; Université de Liège - ULiège > TERRA Research Centre

Chen, L.; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China

Gao, X.; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China

Zou, R.; Graduate School, Chinese Academy of Agricultural Sciences, Beijing, 100081, China

Meng, Q.; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China

Fu, Q.; Proteomics and Metabolomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY 14853, United States

Xie, Y.; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China

Miao, Q.; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China

Chen, L.; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China

Tang, X.; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China

More authors (3 more)

Language :

English

Title :

Quantitative proteomics reveals tissue-specific toxic mechanisms for acute hydrogen sulfide-induced injury of diverse organs in pig

Publication date :

2022

Journal title :

Science of the Total Environment

ISSN :

0048-9697

eISSN :

1879-1026

Publisher :

Elsevier B.V.

Volume :

806

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

China Scholarship Council, CSC: 202003250080; National Key Research and Development Program of China, NKRDPC: 2016YFD0500501

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