Potentialiser la perte de poids avec les agonistes des récepteurs du GLP-1.

Scheen, André; Paquot, Nicolas

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Potentialiser la perte de poids avec les agonistes des récepteurs du GLP-1.

Scheen, André; Paquot, Nicolas

2021 • In Revue Médicale Suisse, 17 (747), p. 1405-1410

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https://hdl.handle.net/2268/264349

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34431633

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Keywords :

Diabetes Mellitus, Type 2/drug therapy; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Pharmaceutical Preparations; Weight Loss

Abstract :

[en] Glucagon-like peptide-1 receptor agonists are the antidiabetic agents that are associated with the greatest weight loss beyond a marked reduction in glycated haemoglobin. Weight loss results from a reduction in appetite through a predominant central effect combined with a peripheral effect. Liraglutide and semaglutide are developed for the treatment of obesity, independently of type 2 diabetes. Three approaches may be considered to potentiate weight loss: an increase of the drug dosage because of the demonstration of a dose-response, an add-on therapy with a sodium-glucose cotransporter type 2 inhibitor as this agent exerts a complementary action through urinary calorie loss (glucosuria) or a combination of the effects of two incretin hormones (GLP-1 and GIP), as the potent dual agonist tirzepatide currently in development.

Disciplines :

Endocrinology, metabolism & nutrition
Pharmacy, pharmacology & toxicology

Author, co-author :

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Paquot, Nicolas ; Université de Liège - ULiège > Département des sciences de la santé publique > Diabétologie, nutrition et maladies métaboliques

Language :

French

Title :

Potentialiser la perte de poids avec les agonistes des récepteurs du GLP-1.

Alternative titles :

[en] Potentiation of weight reduction with GLP-1 receptor agonists

Publication date :

2021

Journal title :

Revue Médicale Suisse

ISSN :

1660-9379

Publisher :

Medecine et Hygiène, Switzerland

Volume :

Issue :

747

Pages :

1405-1410

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 18 October 2021

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Bibliography

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