Optimisation of novel 3D composite scaffolds for bone reconstruction

Custom-made scaffold-mediated regeneration is an emergent field in bone reconstruction. However, the optimization of 3D degradable implants with suitable biological response and mechanical features still remains challenging today. The focus of this study was to tailor a 3D scaffold made from a polymeric macroporous matrix filled with hydroxyapatite (HA) and amphiphilic hydrogel. Accordingly, three different implant designs composed of PLA have been developped by 3D printing with various interconnected porous in an optimal range of 200 to 400 µm. In a second step, the scaffolds have been filled with an amphiphilic gel containing HA in order to optimize the dissolution rate of the gel and its ability to enhance cell colonisation and proliferation.