[en] Restoring damaged β-cells in diabetic patients by harnessing the plasticity of other
pancreatic cells raises the questions of the efficiency of the process and of the
functionality of the new Insulin-expressing cells. To overcome the weak regenerative
capacity of mammals, we used regeneration-prone zebrafish to study β-cells arising
following destruction. We show that most new insulin cells differ from the original β-
cells as they are Somatostatin+ Insulin+, but are nevertheless functional and
normalize glycemia. These bi-hormonal cells are transcriptionally close to a subset
of δ-cells in normal islets characterized by the expression of somatostatin 1.1
(sst1.1), the β-cell genes pdx1, slc2a2 and gck, and the machinery for glucoseinduced
Insulin secretion. β-cell destruction triggers massive sst1.1 δ-cell conversion
to bihormonal cells. Our work shows that their pro- β-cell identity predisposes this
zebrafish δ-cell subpopulation to efficient age-independent neogenesis of
Insulin-producing cells and provides clues to restoring functional β-cells in mammalian
diabetes models.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.