Article (Scientific journals)
Exploratory Assessment of Oxygen Flow–Assisted Cutaneous Administration of Methotrexate for Superficial Basal Cell Carcinoma, Mycosis Fungoides, and Extramammary Paget Disease
LEBAS, Eve; CHAPELIER, Corinne; QUATRESOOZ, Pascale et al.
2019In Journal of Investigative Dermatology, 140 (3), p. 583-592
Peer Reviewed verified by ORBi
 

Files


Full Text
Exploratory Assessment...Disease.pdf
Publisher postprint (2.48 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Article; Paget skin disease; Administration, Cutaneous; Aged; Aged, 80 and over; Biopsy; Carcinoma, Basal Cell; Drug Carriers; Female; Humans; Male; Methotrexate; Middle Aged; Mycosis Fungoides; Oxygen; Paget Disease, Extramammary; Permeability; Pilot Projects; Severity of Illness Index; Skin; Skin Neoplasms; Tissue Distribution; Treatment Outcome
Abstract :
[en] The molecular weight of methotrexate (MTX) makes cutaneous penetration difficult. Oxygen flow could enhance the skin permeation of MTX diluted in the proprietary LP3 carrier system. This pilot study aims to assess the efficacy, safety, and tolerance of oxygen flow-assisted LP3-MTX3% for treating superficial skin cancers. Patients with superficial basal cell carcinoma (n = 12), extramammary Paget disease (n = 5), classic mycosis fungoides (MF; n = 10), and folliculotropic MF (n = 6) were included in the study and were treated with four weekly applications of oxygen flow-assisted LP3-MTX3%. Photographs and biopsies were performed before and one month after treatment. At one month after treatment, the mean superficial basal cell carcinoma erythema-crusting-thickness clinical score, the extramammary Paget disease erythema-oozing-scaling/hyperkeratosis-pain/pruritus clinical score, and the modified composite assessment of index lesion severity classic MF and folliculotropic MF scores were improved by 77.5% ± 17.1% (P < 0.0001), 66.7% ± 22.9% (P = 0.011), 51.3% ± 32.2% (P = 0.0007), and 27.8% ± 32.0% (P = 0.086), respectively. At one month after treatment, histology revealed partial and total clearances for superficial basal cell carcinoma (1/12, 11/12), extramammary Paget disease (4/5, 1/5), classic MF (8/10, 2/10), and folliculotropic MF (6/6, 0/6). Tolerance was excellent and no pain was observed. MTX was never detectable in serum at baseline and 1, 2, 3, 8, 24, 48, and 72 hours post-treatment. In conclusion, the interesting therapeutic efficacy of oxygen flow-assisted LP3-MTX3% for treating superficial basal cell carcinoma, extramammary Paget disease, and MF lesions prompts further studies on a larger scale. Copyright © 2019 The Authors.
Disciplines :
Dermatology
Author, co-author :
LEBAS, Eve ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de dermatologie
CHAPELIER, Corinne ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de dermatologie
QUATRESOOZ, Pascale  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire histologie
SEIDEL, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur d'appui à la recherche clinique et biostatistique
NIKKELS, Arjen ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de dermatologie
Language :
English
Title :
Exploratory Assessment of Oxygen Flow–Assisted Cutaneous Administration of Methotrexate for Superficial Basal Cell Carcinoma, Mycosis Fungoides, and Extramammary Paget Disease
Alternative titles :
[en] Évaluation exploratoire de l'administration cutanée assistée par flux d'oxygène de méthotrexate pour le carcinome basocellulaire superficiel, la mycose fongoïde et la maladie extramammaire de Paget
Publication date :
09 September 2019
Journal title :
Journal of Investigative Dermatology
ISSN :
0022-202X
eISSN :
1523-1747
Publisher :
Elsevier, United Kingdom
Volume :
140
Issue :
3
Pages :
583-592
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 October 2021

Statistics


Number of views
64 (3 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
8
Scopus citations®
without self-citations
5
OpenCitations
 
3

Bibliography


Similar publications



Contact ORBi