Article (Scientific journals)
Anticoagulation des patients diabétiques avec fibrillation auriculaire non valvulaire.
Scheen, André; SPRYNGER, Muriel; Lancellotti, Patrizio
2021In Revue Médicale de Liège, 76 (2), p. 93-97
Peer reviewed
 

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Keywords :
Administration, Oral; Anticoagulants/adverse effects; Atrial Fibrillation/complications/drug therapy; Diabetes Mellitus/drug therapy; Humans; Stroke/etiology/prevention & control; Warfarin/therapeutic use; Atrial fibrillation; Diabetes mellitus; Embolism; Haemorrhage; Anticoagulation
Abstract :
[en] Patients with diabetes have a higher risk of nonvalvular atrial fibrillation (NVAF), cerebral embolisms and anticoagulant-related intracranial bleeding when compared to nondiabetic patients. Non-vitamin K oral anticoagulants (NOACs) are progressively replacing antivitamin K agents among patients with NVAF. They are as efficacious as warfarin to reduce the risk of cerebral and systemic embolisms while reducing the risk of both severe and cerebral hemorrhages. Four studies reported results of prespecified subanalyses that compared results of efficacy and safety of NOACs (dabigatran, rivaroxaban, apixaban, edoxaban) in patients with and without diabetes, overall with similar results in both subgroups. ENGAGE AF-TIMI 48 is the only trial that reported a significant reduction of severe hemorrhages with edoxaban compared with warfarin in diabetic patients with NVAF.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
SPRYNGER, Muriel ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Angéiologie
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Language :
French
Title :
Anticoagulation des patients diabétiques avec fibrillation auriculaire non valvulaire.
Alternative titles :
[en] Anticoagulation of diabetic patients with nonvalvular atrial fibrillation
Publication date :
2021
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
76
Issue :
2
Pages :
93-97
Peer reviewed :
Peer reviewed
Available on ORBi :
since 02 September 2021

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