Efficacy and safety of tianeptine in the treatment of depressive disorders in comparison with fluoxetine

Depressive Disorders; Fluoxetine; Tianeptine; Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Thiazepines; Treatment Outcome

Abstract :

[en] Background: Depression is treated by a great variety of antidepressant treatments. SSRIs (such as fluoxetine) are well known: it is, however, sure that further progress is needed and the search for antidepressants with other mechanisms of action (such as tianeptine) or different efficacy is still of interest. Methods: A multinational study compared tianeptine with fluoxetine in 387 patients with Depressive Episode, or Recurrent Depressive Disorder, or Bipolar Affective Disorder (ICD-10), in a double-blind parallel group design. They were treated for six weeks. Results: At inclusion, no significant difference between groups was shown. Final MADRS scores were 15.7 and 15.8 with tianeptine and fluoxetine, respectively (ITT population) (p=0.944). MADRS responders were 58% and 56% with tianeptine and fluoxetine, respectively (p=0.710). No statistical difference was observed for the other efficacy parameters. Thirty-six withdrawals occurred in each group, without any difference for the reasons of discontinuation. There was no major difference between groups for the other safety parameters. Conclusions: In this study, both tianeptine and fluoxetine exhibited a good efficacy and safety. Copyright (C) 1999 Elsevier Science B.V.

Disciplines :

Treatment & clinical psychology

Author, co-author :

Lôo, H.; Serv. Hosp. Univ. S. Mentale T., Sainte-Anne Hosp., 7 R. C., Paris, France

Saiz-Ruiz, J.; Ramon Y Cajal Hospital, Department of Psychiatry, Madrid, Spain

Costa E Silva, J. A.; University Hospital, Faculty of Medicine, Rio de Janeiro, Brazil

ANSSEAU, Marc ; Université de Liège - ULg

Herrington, R.; Gartnavel Royal Hospital, Scotland, Glasgow, United Kingdom

Vaz-Serra, A.; University Hospital, Department of Psychiatry, Coimbra, Portugal

Dilling, H.; University Hospital, Clinic of Psychiatry, Lübeck, Germany

De Risio, S.; Catholic University del Sacro Cuore, Inst. of Psychiatry and Psychology, Roma, Italy

Language :

English

Title :

Efficacy and safety of tianeptine in the treatment of depressive disorders in comparison with fluoxetine

Publication date :

1999

Journal title :

Journal of Affective Disorders

ISSN :

0165-0327

eISSN :

1573-2517

Publisher :

Elsevier, Netherlands

Volume :

Issue :

2-3

Pages :

109-118

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 August 2021

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