Essential oil-based bioherbicides: human health risks analysis

[en] : In recent years, the development of new bio‐based products for biocontrol has been gain‐ ing importance as it contributes to reducing the use of synthetic herbicides in agriculture. Conven‐ tional herbicides (i.e., the ones with synthetic molecules) can lead to adverse effects such as human diseases (cancers, neurodegenerative diseases, reproductive perturbations, etc.) but also to disturb‐ ing the environment because of their drift in the air, transport throughout aquatic systems and per‐ sistence across different environments. The use of natural molecules seems to be a very good alter‐ native for maintaining productive agriculture but without the negative side effects of synthetic herb‐ icides. In this context, essential oils and their components are increasingly studied in order to pro‐ duce several categories of biopesticides thanks to their well‐known biocidal activities. However, these molecules can also be potentially hazardous to humans and the environment. This article re‐ views the state of the literature and regulations with regard to the potential risks related to the use of essential oils as bioherbicides in agricultural and horticultural applications.

Disciplines :

Agriculture & agronomy
Chemistry

Author, co-author :

Maes, Chloé ; Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes

Meersmans, Jeroen ; Université de Liège - ULiège > Département GxABT > Echanges Eau - Sol - Plantes

Lins, Laurence ; Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes

Bouquillon, sandrine; Université Reims-Champagne-Ardenne

Fauconnier, Marie-Laure ; Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes

Language :

English

Title :

Essential oil-based bioherbicides: human health risks analysis

Publication date :

September 2021

Journal title :

International Journal of Molecular Sciences

ISSN :

1661-6596

eISSN :

1422-0067

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 August 2021

Statistics

Number of views

135 (25 by ULiège)

Number of downloads

107 (7 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Kim, K.‐H.; Kabir, E.; Jahan, S.A. Exposure to pesticides and the associated human health effects. Sci. Total Environ. 2017, 575, 525–535, doi:10.1016/j.scitotenv.2016.09.009.
Scavo, A.; Mauromicale, G. Integrated weed management in herbaceous field crops. Agronomy 2020, 10, 466, doi:10.3390/agron-omy10040466.
Ben Kaab, S.; Rebey, I.B.; Hanafi, M.; Berhal, C.; Fauconnier, M.L.; De Clerck, C.; Ksouri, R.; Jijakli, H. Rosmarinus officinalis essential oil as an effective antifungal and herbicidal agent. Span. J. Agric. Res. 2019, 17, e1006, doi:10.5424/sjar/2019172‐14043.
De Clerck, C.; Maso, S.D.; Parisi, O.; Dresen, F.; Zhiri, A.; Jijakli, M.H. Screening of antifungal and antibacterial activity of 90 commercial essential oils against 10 pathogens of agronomical importance. Foods 2020, 9, 1418, doi:10.3390/foods9101418.
Tanoh, E.A.; Boué, G.B.; Nea, F.; Genva, M.; Wognin, E.L.; LeDoux, A.; Martin, H.; Tonzibo, Z.F.; Frederich, M.; Fauconnier, M.‐ L. Seasonal effect on the chemical composition, insecticidal properties and other biological activities of Zanthoxylum leprieurii guill. & perr. essential oils. Foods 2020, 9, 550, doi:10.3390/foods9050550.
Maes, C.; Bouquillon, S.; Fauconnier, M.‐L. Encapsulation of essential oils for the development of biosourced pesticides with controlled release: A review. Molecules 2019, 24, 2539, doi:10.3390/molecules24142539.
Werrie, P.‐Y.; Durenne, B.; Delaplace, P.; Fauconnier, M.‐L. Phytotoxicity of essential oils: Opportunities and constraints for the development of biopesticides. A review. Foods 2020, 9, 1291, doi:10.3390/foods9091291.
Baser, K.H.C.; Buchbauer, G. Handbook of Essential Oils, 3rd ed.; CRC Press: Boca Raton, FL, USA, 2020; ISBN 9781351246460.
Villaverde, J.J.; Sandín‐España, P.; Sevilla‐Morán, B.; López‐Goti, C.; Alonso‐Prados, J.L. Biopesticides from Natural Products: Current Development, Legislative Framework, and Future Trends. BioResources 2016, 11, 5618–5640, doi:10.15376/bio-res.11.2.villaverde.
Raveau, R.; Fontaine, J.; Sahraoui, A.L.‐H. Essential oils as potential alternative biocontrol products against plant pathogens and weeds: A review. Foods 2020, 9, 365, doi:10.3390/foods9030365.
Zhang, L.; Rana, I.; Shaffer, R.M.; Taioli, E.; Sheppard, L. Exposure to glyphosate‐based herbicides and risk for non‐Hodgkin lymphoma: A meta‐analysis and supporting evidence. Mutat. Res.‐Rev. Mutat. Res. 2019, 781, 186–206, doi:10.1016/j.mrrev.2019.02.001.
Van Bruggen, A.; He, M.; Shin, K.; Mai, V.; Jeong, K.; Finckh, M.; Morris, J. Environmental and health effects of the herbicide glyphosate. Sci. Total. Environ. 2018, 616–617, 255–268, doi:10.1016/j.scitotenv.2017.10.309.
Martínez, M.‐A.; Ares, I.; Rodríguez, J.‐L.; Martínez, M.; Martínez‐Larrañaga, M.‐R.; Anadón, A. Neurotransmitter changes in rat brain regions following glyphosate exposure. Environ. Res. 2018, 161, 212–219, doi:10.1016/j.envres.2017.10.051.
Battaglin, W.A.; Meyer, M.; Kuivila, K.M.; Dietze, J. Glyphosate and its degradation product AMPA occur frequently and widely in U.S. soils, surface water, groundwater, and precipitation. JAWRA J. Am. Water Resour. Assoc. 2014, 50, 275–290, doi:10.1111/jawr.12159.
Colosio, C.; Rubino, F.M.; Moretto, A. Pesticides. In International Encyclopedia of Public Health; Academic Press: Cambridge, MA, USA, 2017; pp. 454–462.
Zimdahl, R. Herbicides and the environment. In Fundamentals of Weed Science, 5th ed.; Elsevier: Amsterdam, The Netherlands, 2018; pp. 557–590, ISBN 9780128111437.
Richardson, J.; Grosskopf, C.; Hamey, P.Y.; Machera, K.; Martin, S.; Jacobi, L.E.; Tiramani, M. Guidance on the assessment of exposure of operators, workers, residents and bystanders in risk assessment for plant protection products. EFSA J. 2014, 12, 3874, doi:10.2903/j.efsa.2014.3874.
Fita, A.; Rodríguez‐Burruezo, A.; Boscaiu, M.; Prohens, J.; Vicente, O. Breeding and domesticating crops adapted to drought and salinity: A new paradigm for increasing food production. Front. Plant Sci. 2015, 6, 978, doi:10.3389/fpls.2015.00978.
Juroszek, P.; Von Tiedemann, A. Potential strategies and future requirements for plant disease management under a changing climate. Plant Pathol. 2011, 60, 100–112, doi:10.1111/j.1365‐3059.2010.02410.x.
Mithila, J.; Hall, J.C.; Johnson, W.; Kelley, K.B.; Riechers, D.E. Evolution of resistance to auxinic herbicides: Historical perspec-tives, mechanisms of resistance, and implications for broadleaf weed management in agronomic crops. Weed Sci. 2011, 59, 445– 457, doi:10.1614/ws‐d‐11‐00062.1.
Duke, S.O. Glyphosate: Uses other than in glyphosate‐resistant crops, mode of action, degradation in plants, and effects on non-target plants and agricultural microbes. In Reviews of Environmental Contamination and Toxicology; Springer: Berlin/Heidelberg, Germany, 2020.
De María, N.; Becerril, J.M.; Garcia‐Plazaola, J.I.; Hernández, A.; De Felipe, M.R.; Fernández‐Pascual, M. New insights on glyphosate mode of action in nodular metabolism: Role of shikimate accumulation. J. Agric. Food Chem. 2006, 54, 2621–2628, doi:10.1021/jf058166c.
Lu, H.; Yu, Q.; Han, H.; Owen, M.J.; Powles, S.B. Metribuzin resistance in a wild radish (Raphanus raphanistrum) population via both psbA gene mutation and enhanced metabolism. J. Agric. Food Chem. 2019, 67, 1353–1359, doi:10.1021/acs.jafc.8b05974.
Ciriminna, R.; Fidalgo, A.; Ilharco, L.M.; Pagliaro, M. Herbicides based on pelargonic acid: Herbicides of the bioeconomy. Bio-fuels Bioprod. Biorefin. 2019, 13, 1476–1482, doi:10.1002/bbb.2046.
Fukuda, M.; Tsujino, Y.; Fujimori, T.; Wakabayashi, K.; Böger, P. Phytotoxic activity of middle‐chain fatty acids I: Effects on cell constituents. Pestic. Biochem. Physiol. 2004, 80, 143–150, doi:10.1016/j.pestbp.2004.06.011.
Motmainna, M.; Juraim, A.S.B.; Uddin, J.M.K.; Asib, N.B.; Islam, A.M.; Hasan, M. Assessment of allelopathic compounds to develop new natural herbicides: A review. Allelopath. J. 2021, 52, 21–40, doi:10.26651/allelo.j/2021‐52‐1‐1305.
Donley, N. The USA lags behind other agricultural nations in banning harmful pesticides. Environ. Health 2019, 18, 44, doi:10.1186/s12940‐019‐0488‐0.
Braga, A.R.C.; De Rosso, V.V.; Harayashiki, C.A.Y.; Jimenez, P.C.; Castro, B. Global health risks from pesticide use in Brazil. Nat. Food 2020, 1, 312–314, doi:10.1038/s43016‐020‐0100‐3.
Skevas, T.; Lansink, A.O.; Stefanou, S. Designing the emerging EU pesticide policy: A literature review. NJAS‐Wagening. J. Life Sci. 2012, 64‐65, 95–103, doi:10.1016/j.njas.2012.09.001.
Zhao, L.; Wang, C.; Gu, H.; Yue, C. Market incentive, government regulation and the behavior of pesticide application of vege-table farmers in China. Food Control 2018, 85, 308–317, doi:10.1016/j.foodcont.2017.09.016.
Handford, C.E.; Elliott, C.T.; Campbell, K. A review of the global pesticide legislation and the scale of challenge in reaching the global harmonization of food safety standards. Integr. Environ. Assess. Manag. 2015, 11, 525–536, doi:10.1002/ieam.1635.
Francis, F.; Jacquemyn, H.; Delvigne, F.; Lievens, B. From Diverse Origins to Specific targets: Role of microorganisms in indirect pest biological control. Insects 2020, 11, 533, doi:10.3390/insects11080533.
Eddaya, T.; Boughdad, A.; Becker, L.; Chaimbault, P.; Zaïd, A. Use and risks of pesticides in sanitary protection of spearmint in South‐Central Morocco. J. Mater. Environ. Sci. 2015, 6, 656–665.
Ninkuu, V.; Zhang, L.; Yan, J.; Fu, Z.; Yang, T.; Zeng, H. Biochemistry of terpenes and recent advances in plant protection. Int. J. Mol. Sci. 2021, 22, 5710, doi:10.3390/ijms22115710.
Bakkali, F.; Averbeck, S.; Idaomar, M. Biological effects of essential oils—A review. Food Chem. Toxicol. 2008, 46, 446–475, doi:10.1016/j.fct.2007.09.106.
Gruľová, D.; Caputo, L.; Elshafie, H.S.; Baranová, B.; De Martino, L.; Sedlák, V.; Gogaľová, Z.; Poráčová, J.; Camele, I.; De Feo, V. Thymol chemotype Origanum vulgare L. essential oil as a potential selective bio‐based herbicide on monocot plant species. Molecules 2020, 25, 595, doi:10.3390/molecules25030595.
De Martino, L.; Mancini, E.; De Almeida, L.F.R.; De Feo, V. The antigerminative activity of twenty‐seven monoterpenes. Molecules 2010, 15, 6630–6637, doi:10.3390/molecules15096630.
Koul, O.; Walia, S.; Dhaliwal, G.S. Essential oils as green pesticides: Potential and constraints. Biopestic. Int. 2008, 4, 63–84.
Weis, G.C.C.; Alves, A.D.O.; Assmann, C.E.; Bonadiman, B.D.S.R.; Costabeber, I.H. Pesticides: Classifications, exposure and risks to human health. Arch. Biosci. Health 2019, 1, 29–44, doi:10.18593/abh.17454.
Yadav, I.C.; Linthoingambi, N.D. Pesticides classification and its impact on human and environment. Environ. Sci. Eng. 2017, 6, 140–158.
Lins, L.; Maso, S.D.; Foncoux, B.; Kamili, A.; Laurin, Y.; Genva, M.; Jijakli, M.H.; De Clerck, C.; Fauconnier, M.L.; Deleu, M. Insights into the relationships between herbicide activities, molecular structure and membrane interaction of cinnamon and citronella essential oils components. Int. J. Mol. Sci. 2019, 20, 4007, doi:10.3390/ijms20164007.
Martins, C.; Rueff, J.; Rodrigues, A.S. Genotoxic alkenylbenzene flavourings, a contribution to risk assessment. Food Chem. Tox-icol. 2018, 118, 861–879, doi:10.1016/j.fct.2018.06.020.
Obolskiy, D.; Pischel, I.; Feistel, B.; Glotov, N.; Heinrich, M. Artemisia dracunculus L. (Tarragon): A critical review of its traditional use, chemical composition, pharmacology, and safety. J. Agric. Food Chem. 2011, 59, 11367–11384, doi:10.1021/jf202277w.
de Groot, A.C.; Schmidt, E. Essential Oils: Contact Allergy and Chemical Composition; Routledge: Boca Raton, FL, USA, 1998; Vol-ume 54.
Scientific Committee on Consumer Safety. Opinion on Fragrance Allergens in Cosmetic Products; SCCS/1459/11; Scientific Committee on Consumer Safety: Brussels, Belgium, 2012; pp. 2–334.
Nathalie, D.; Yannick, G.; Caroline, B.; Sandrine, D.; Claude, F.; Corinne, C.; Pierre‐Jacques, F. Assessment of the phototoxic hazard of some essential oils using modified 3T3 neutral red uptake assay. Toxicol. Vitr. 2006, 20, 480–489, doi:10.1016/j.tiv.2005.08.018.
Dosoky, N.; Setzer, W. Maternal reproductive toxicity of some essential oils and their constituents. Int. J. Mol. Sci. 2021, 22, 2380, doi:10.3390/ijms22052380.
Dhifi, W.; Bellili, S.; Jazi, S.; Bahloul, N.; Mnif, W. Essential Oils’ Chemical characterization and investigation of some biological activities: A critical review. Medicines 2016, 3, 25, doi:10.3390/medicines3040025.
Maralhas, A.; Monteiro, A.; Martins, C.; Kranendonk, M.; Laires, A.; Rueff, J.; Rodrigues, A.S. Genotoxicity and endoreduplica-tion inducing activity of the food flavouring eugenol. Mutagenesis 2006, 21, 199–204, doi:10.1093/mutage/gel017.
Bleasel, N.; Tate, B.; Rademaker, M. Allergic contact dermatitis following exposure to essential oils. Australas. J. Dermatol. 2002, 43, 211–213, doi:10.1046/j.1440‐0960.2002.00598.x.
Ackermann, L.; Jolanki, R.; Alanko, K.; Aalto‐Korte, K. Occupational allergic contact dermatitis from cinnamon including one case from airborne exposure. Contact Dermat. 2009, 60, 96–99, doi:10.1111/j.1600‐0536.2008.01486.x.
Trattner, A.; David, M.; Lazarov, A. Occupational contact dermatitis due to essential oils. Contact Dermat. 2008, 58, 282–284, doi:10.1111/j.1600‐0536.2007.01275.x.
Türkmenoğlu, A.; Özmen, D. Allergenic components, biocides, and analysis techniques of some essential oils used in food products. J. Food Sci. 2021, 86, 2225–2241, doi:10.1111/1750‐3841.15753.
Nurmatov, U.B.; Tagiyeva, N.; Semple, S.; Devereux, G.; Sheikh, A. Volatile organic compounds and risk of asthma and allergy: A systematic review. Eur. Respir. Rev. 2015, 24, 92–101, doi:10.1183/09059180.00000714.
Levy, J.; Neukirch, C.; Larfi, I.; Demoly, P.; Thabut, G. Tolerance to exposure to essential oils exposure in patients with allergic asthma. J. Asthma 2018, 56, 853–860, doi:10.1080/02770903.2018.1493601.
Dhakad, A.K.; Pandey, V.V.; Beg, S.; Rawat, J.M.; Singh, A. Biological, medicinal and toxicological significance of eucalyptus leaf essential oil: A review. J. Sci. Food Agric. 2017, 98, 833–848, doi:10.1002/jsfa.8600.
Mossa, A.‐T. Green Pesticides: Essential Oils as Biopesticides in Insect‐pest Management. J. Environ. Sci. Technol. 2016, 9, 354– 378, doi:10.3923/jest.2016.354.378.
Geng, S.; Cui, Z.; Huang, X.; Chen, Y.; Xu, D.; Xiong, P. Variations in essential oil yield and composition during Cinnamomum cassia bark growth. Ind. Crop. Prod. 2011, 33, 248–252, doi:10.1016/j.indcrop.2010.10.018.
Jijakli, H.; Dal Maso, S.; Parisi, O. Bio‐Herbicide Based on Essential Oil. International Patent WO 2019/238948 A1,19 December 2019.
Su, H.‐J.; Chao, C.‐J.; Chang, H.‐Y.; Wu, P.‐C. The effects of evaporating essential oils on indoor air quality. Atmos. Environ. 2007, 41, 1230–1236, doi:10.1016/j.atmosenv.2006.09.044.
Angulo‐Milhem, S.; Verriele, M.; Nicolas, M.; Thevenet, F. Indoor use of essential oils: Emission rates, exposure time and impact on air quality. Atmos. Environ. 2020, 244, 117863, doi:10.1016/j.atmosenv.2020.117863.
Huang, X.; He, J.; Yan, X.; Hong, Q.; Chen, K.; He, Q.; Zhang, L.; Liu, X.; Chuang, S.; Li, S.; et al. Microbial catabolism of chemical herbicides: Microbial resources, metabolic pathways and catabolic genes. Pestic. Biochem. Physiol. 2017, 143, 272–297, doi:10.1016/j.pestbp.2016.11.010.
Chawla, P.; Kaushik, R.; Swaraj, V.S.; Kumar, N. Organophosphorus pesticides residues in food and their colorimetric detection. Environ. Nanotechnol. Monit. Manag. 2018, 10, 292–307, doi:10.1016/j.enmm.2018.07.013.
European Food Safety Authority. Reporting data on pesticides residues in food and feeding according to Regulation (EC) No 396/2005 (2015 data collection). EFSA J. 2016, 14, e04496.