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COVID-19 in liver transplant candidates: wait-list outcomes and post-transplant course
Perricone, G; Duvoux, C; Mazzarelli, C et al.
2021In Transplant International, 34 (S1 OP232), p. 41
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Abstract :
[en] Background: The impact of prior SARS-CoV-2 infection on patients on the waiting list for liver transplantation (LT) and on their post-LT course is presently unknown. Methods: Data from adult LT candidates with laboratory confirmed SARSCoV- 2 infection was collected across Europe and all consecutive patients with symptomatic COVID-19 were included in the analysis. Results: From February 21st to November 20th, 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 infection from 33 centers in 10 European countries were collected, with 113 having symptomatic COVID-19. Thirtythree (29.2%) were managed as outpatients, 80 (70.8%) required hospitalization including admission to the intensive care unit (28/80, 35%). Thirtyseven (37/113, 32.7%) patients died after a median of 18 (10-30) days, respiratory failure being the major cause (33/37, 89.2%). The 60-day mortality risk did not change between first (35.3%, 95% CI 23.9-50.0) and second wave (26.0%, 95% CI 16.2-40.2). Multivariable Cox regression analysis showed MELD score !15 (MELD15-19:HR 6.09 95%CI 2.01-18.44; MELD ! 20:HR 5.21, 95%CI 1.76-15.45) and dyspnea on presentation (HR:4.1, 95%CI 2.09-8.06) being the two negative independent factors for mortality. Twenty-six patient received a LT after a median time of 78.5 (IQR:44-102) days and 25 are alive after a median follow-up of 118 days (IQR:31-170). Conclusions: Mortality of LT candidates with symptomatic COVID-19 was high (32.7%) peaking at 45% in decompensated cirrhotic with MELD > 15 and did not significantly differ between the 2 waves of the pandemic, respiratory failure being the major cause of death thus supporting high priority for vaccination. Prior SARS-CoV-2 infection did not affect early post-transplant survival (96%). ª
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Perricone, G
Duvoux, C
Mazzarelli, C
Vigano, R
Facchetti, R
Cortesi, P
Iacob, S
Radenne, S
Patrono, D
Berlakovich, GA
Hann, A
Pasulo, L
Castel, L
Faitot, F
DETRY, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Chirurgie abdo, sénologique, endocrine et de transplantation
Invernizzi, F
Magini, G
De Simone, P
Kounis, I
Morelli, MC
Diaz, F
Erczon, BG
Loinaz, C
Johnston, C
Elkrief, L
Fondevilla, C
Polak, W
Belli, L
More authors (18 more) Less
Language :
Title :
COVID-19 in liver transplant candidates: wait-list outcomes and post-transplant course
Publication date :
August 2021
Event name :
ESOT 2021 Milan
Event organizer :
European Society of Transplantation
Event place :
Milan, Italy
Event date :
Du 29 aout au 1 septembre 2021
Audience :
Journal title :
Transplant International
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
Issue :
S1 OP232
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
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since 29 August 2021


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