Article (Scientific journals)
Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.
Claassen, Jan; Akbari, Yama; Alexander, Sheila et al.
2021In Neurocritical Care, 35 (Suppl 1), p. 4-23
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Keywords :
Biomarkers; Coma; Consciousness; Electrophysiology; Magnetic resonance imaging
Abstract :
[en] Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.
Disciplines :
Neurology
Author, co-author :
Claassen, Jan
Akbari, Yama
Alexander, Sheila
Bader, Mary Kay
Bell, Kathleen
Bleck, Thomas P.
Boly, Melanie
Brown, Jeremy
Chou, Sherry H.-Y.
Diringer, Michael N.
Edlow, Brian L.
Foreman, Brandon
Giacino, Joseph T.
Gosseries, Olivia  ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group
Green, Theresa
Greer, David M.
Hanley, Daniel F.
Hartings, Jed A.
Helbok, Raimund
Hemphill, J. Claude
Hinson, H. E.
Hirsch, Karen
Human, Theresa
James, Michael L.
Ko, Nerissa
Kondziella, Daniel
Livesay, Sarah
Madden, Lori K.
Mainali, Shraddha
Mayer, Stephan A.
McCredie, Victoria
McNett, Molly M.
Meyfroidt, Geert
Monti, Martin M.
Muehlschlegel, Susanne
Murthy, Santosh
Nyquist, Paul
Olson, Daiwai M.
Provencio, J. Javier
Rosenthal, Eric
Sampaio Silva, Gisele
Sarasso, Simone
Schiff, Nicholas D.
Sharshar, Tarek
Shutter, Lori
Stevens, Robert D.
Vespa, Paul
Videtta, Walter
Wagner, Amy
Ziai, Wendy
Whyte, John
Zink, Elizabeth
Suarez, Jose I.
More authors (43 more) Less
Language :
English
Title :
Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.
Publication date :
2021
Journal title :
Neurocritical Care
ISSN :
1541-6933
eISSN :
1556-0961
Publisher :
Humana Press, United States
Volume :
35
Issue :
Suppl 1
Pages :
4-23
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 August 2021

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