Article (Scientific journals)
LDLR expression in the cochlea suggests a role in endolymph homeostasis and cochlear amplification
Saume, Aurore; Thiry, Marc; Defourny, Jean
2021In Hearing Research
Peer Reviewed verified by ORBi


Full Text
Saume et al., 2021 .pdf
Publisher postprint (3.35 MB)

All documents in ORBi are protected by a user license.

Send to


Keywords :
Cochlea; Deiters’ cells; Endolymph; LDLR; Pillar cells; Stria vascularis
Abstract :
[en] There is now growing evidence that hypercholesterolemia and high serum levels of low-density lipoproteins (LDL) predispose to sensorineural hearing loss. Circulating LDL-cholesterol is delivered to peripheral tissues via LDL receptor (LDLR) -mediated endocytosis. Recently, it has been shown that LDLR gene polymorphisms are associated with higher susceptibility to sudden deafness. These findings suggested that we should investigate the expression of LDLR from the postnatal maturation of the mouse cochlea until adulthood. In the cochlea of newborn mice, we observed that LDLR is mostly expressed in the lateral wall of the cochlea, especially in a band of cells directly facing the cochlear duct. Moreover, LDLR is expressed in the inner and outer hair cells, as well as in the adjacent greater epithelial ridge. In early postnatal stages, LDLR is expressed in the marginal cells of the immature stria vascularis, in the root cells of the spiral ligament, and in the adjacent outer sulcus cells. At the same time, LDLR begins to be expressed in the pillar cells of the immature organ of Corti. From the onset of hearing, LDLR is expressed in the marginal cells of the stria vascularis, in the outer sulcus cells, and in the capillaries of the adjacent spiral ligament. In the organ of Corti, LDLR is expressed in outer pillar cells and Deiters' cells, i.e. in the non-sensory supporting cells that directly surround the outer hair cells. These cells are believed to provide a mechanical coupling with the outer hair cells to modulate electromotility and cochlear amplification. In the stria vascularis of three-month-old mice, LDLR is further expressed in both marginal and intermediate cells. Overall, our results suggest that LDLR is mostly present in cochlear cells that are involved in endolymph homeostasis and cochlear amplification. Further functional studies will be needed to unravel how LDLR regulates extracellular and intracellular levels of cholesterol and lipoproteins in the cochlea, and how it could influence cochlear homeostasis.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Saume, Aurore ;  Université de Liège - ULiège > Master bioch. & biol. mol. & cel., à fin.
Thiry, Marc  ;  Université de Liège - ULiège > Département des sciences de la vie > Biologie cellulaire
Defourny, Jean  ;  Université de Liège - ULiège > GIGA Neurosciences - Cellular and tissular biology
Language :
Title :
LDLR expression in the cochlea suggests a role in endolymph homeostasis and cochlear amplification
Publication date :
15 July 2021
Journal title :
Hearing Research
Publisher :
Elsevier, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 02 August 2021


Number of views
752 (363 by ULiège)
Number of downloads
202 (5 by ULiège)

Scopus citations®
Scopus citations®
without self-citations


Similar publications

Contact ORBi