Article (Scientific journals)
Circulating Nucleosomes as Potential Markers to Monitor COVID-19 Disease Progression.
Cavalier, Etienne; Guiot, Julien; Lechner, Katharina et al.
2021In Frontiers in Molecular Biosciences, 8, p. 600881
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Keywords :
biomarkers; COVID-19; NETosis; SARS nucleosomes; citrullination; liquid biopsy; neutrophil extracellular traps
Abstract :
[en] The severity of coronavirus disease 2019 (COVID-19) varies significantly with cases spanning from asymptomatic to lethal with a subset of individuals developing Severe Acute Respiratory Syndrome (SARS) and death from respiratory failure. To determine whether global nucleosome and citrullinated nucleosome levels were elevated in COVID-19 patients, we tested two independent cohorts of COVID-19 positive patients with quantitative nucleosome immunoassays and found that nucleosomes were highly elevated in plasma of COVID-19 patients with a severe course of the disease relative to healthy controls and that both histone 3.1 variant and citrullinated nucleosomes increase with disease severity. Elevated citrullination of circulating nucleosomes is indicative of neutrophil extracellular trap formation, neutrophil activation and NETosis in severely affected individuals. Importantly, using hospital setting (outpatient, inpatient or ICU) as a proxy for disease severity, nucleosome levels increased with disease severity and may serve as a guiding biomarker for treatment. Owing to the limited availability of mechanical ventilators and extracorporal membrane oxygenation (ECMO) equipment, there is an urgent need for effective tools to rapidly assess disease severity and guide treatment selection. Based on our studies of two independent cohorts of COVID-19 patients from Belgium and Germany, we suggest further investigation of circulating nucleosomes and citrullination as biomarkers for clinical triage, treatment allocation and clinical drug discovery.
Disciplines :
Immunology & infectious disease
Laboratory medicine & medical technology
Author, co-author :
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Guiot, Julien  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Lechner, Katharina
Dutsch, Alexander
Eccleston, Mark
Herzog, Marielle
Bygott, Thomas
Schomburg, Adrian
Kelly, Theresa
Holdenrieder, Stefan
Language :
English
Title :
Circulating Nucleosomes as Potential Markers to Monitor COVID-19 Disease Progression.
Publication date :
March 2021
Journal title :
Frontiers in Molecular Biosciences
eISSN :
2296-889X
Publisher :
Frontiers Media S.A., Lausanne, Switzerland
Volume :
8
Pages :
600881
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2021 Cavalier, Guiot, Lechner, Dutsch, Eccleston, Herzog, Bygott, Schomburg, Kelly and Holdenrieder.
Available on ORBi :
since 26 July 2021

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