Reference : A double-blind comparison of the efficacy and safety of milnacipran and fluoxetine in...
Scientific journals : Article
Social & behavioral sciences, psychology : Treatment & clinical psychology
http://hdl.handle.net/2268/262237
A double-blind comparison of the efficacy and safety of milnacipran and fluoxetine in depressed inpatients
English
Guelfi, J. D. [University Paris XI, Department of Psychiatry, Hôpital Paul Brousse, Villejuif, France, Department of Psychiatry, Hôpital Paul Brousse, 12 Avenue P. Vaillant-Couturier, 94804 Villejuif Cedex, France]
ANSSEAU, Marc mailto [Université de Liège - ULg]
Corruble, E. [University Paris XI, Department of Psychiatry, Hôpital Paul Brousse, Villejuif, France]
Samuelian, J. C. [Department of Psychiatry, CHU La Timone, Marseille, France]
Tonelli, I. [Institut de Recherche Pierrre Fabre, Boulogne, France]
Tournoux, A. [Institut de Recherche Pierrre Fabre, Boulogne, France]
Plétan, Y. [Institut de Recherche Pierrre Fabre, Boulogne, France]
1998
International Clinical Psychopharmacology
Lippincott Williams & Wilkins
13
3
121-128
Yes (verified by ORBi)
International
0268-1315
United States
[en] Antidepressant ; Efficacy ; Fluoxetine ; Major depression ; Milnacipran
[en] This double-blind, randomised, multicentre study compared the antidepressant efficacy and safety of two doses of milnacipran (100 mg/day and 200 mg/day) and fluoxetine (20 mg/day) in 289 inpatients with endogenous depression. After a placebo washout period of 4-7 days, assessments were performed weekly during the first 4 weeks, and then after 6, 8 and 12 weeks, using the 17-item Hamilton Depression Rating Scale (HDRS), the Montgomery- Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression (CGI). HDRS total score was reduced by a mean of 14.8 in the milnacipran 100 mg/day group, 12.9 in the milnacipran 200 mg/day group and 12.1 in the fluoxetine 20 mg/day group. MADRS total score decreased by 17.4, 15.8 and 14.6, respectively. No significant difference could be shown between the three treatment groups for either the HDRS or MADRS total scores. However, the time-by-time change showed a trend in favour of milnacipran 100 mg/day, which was found significantly superior to fluoxetine at day 28 for several converging parameters (MADRS, CGI-3). Overall, efficacy ratings for all parameters were highest for milnacipran 100 mg/day, followed by milnacipran 200 mg/day and fluoxetine 20 mg/day. Side-effect profiles were not significantly different between groups except for a significantly greater frequency of dose-related increase in heart rate ≤ 100 bpm in milnacipran recipients and a significantly greater weight loss in fluoxetine recipients.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/262237
10.1097/00004850-199805000-00005

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